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    Article

    Isolation and Structure Elucidation of Aryltetralin Lignans from Linum tauricum ssp. bulgaricum

    Nikolay P. Vasilev1, Iliana I. Ionkova1★★ Corresponding author

    1. 1Department of Pharmacognosy, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav St, Sofia 1000, Bulgaria.

    CORRESPONDENCE

    Iliana I. Ionkova

    Department of Pharmacognosy, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav St, Sofia 1000, Bulgaria.

    ionkova@pharmfac.acad.bg

    Volume 2, Issue 7 · pp. 172–173 · PUBLISHED 2006 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    A phytochemical investigation of the aerial parts of Linum tauricum ssp. bulgaricum (Linaceae) led to the isolation of five lignans using semi-preparative HPLC. LC-MS and NMR studies were used to characterize the structures of the isolated compounds. This is the first report of podophyllotoxin, 4′-demethylpodophyllotoxin, 4′-demethyl-6-methoxypodophyllotoxin and isolariciresinol in L. tauricum. Thus, the combination of semi-preparative HPLC, LC-MS and NMR techniques represents a powerful tool for unraveling the structure of naturally occurring lignans.

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      Vasilev, N. P., & Ionkova, I. I. (2006). Isolation and Structure Elucidation of Aryltetralin Lignans from Linum tauricum ssp. bulgaricum. Pharmacognosy Magazine, 2(7), 172–173.