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    Article

    The Beneficial Effects of Topical Cream Containing 17% of Herbal Extract on Skin Barrier Function: A Randomized Four-week Trial

    Ji-Hyo Lyu1, Soyeon Kim2★, Kang Kwon3, Yongkuk Kim4, Chanhun Choi5, Hyunwoo Jeong6, Hyungwoo Kim2,7★ Corresponding author

    1. 1Department of Physiology, College of Korean Medicine, Dongshin University, Naju, Republic of Korea Corresponding author: Hyungwoo Kim, National Clinical Research Center for Korean Medicine, Pusan National University Korean Medicine Hospital, Yangsan 50612, Republic of Korea. E-mail: kronos7@pusan.ac.kr.
    2. 2Department of Mathematics, College of Natural Sciences, Kyungpook National University, Daegu, REPUBLIC OF KOREA.
    3. 3Department of Korean Medical Ophthalmology & Otolaryngology & Dermatology, School of Korean Medicine, Pusan National University, Yangsan, REPUBLIC OF KOREA.
    4. 4Research Institute for Korean Medicine, Pusan National University, Yangsan, REPUBLIC OF KOREA.
    5. 5Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju, REPUBLIC OF KOREA.
    6. 6Department of Pathology, College of Korean Medicine, Dongshin University, Naju, REPUBLIC OF KOREA.
    7. 7National Clinical Research Center for Korean Medicine, Pusan National University Korean Medicine Hospital, Yangsan, Republic of Korea.

    CORRESPONDENCE

    Soyeon Kim

    Department of Mathematics, College of Natural Sciences, Kyungpook National University, Daegu, REPUBLIC OF KOREA.

    kronos7@pusan.ac.kr

    Received: 05-10-2023; Accepted: 05-03-2024.

    Volume 20, Issue 3 · pp. 1005–1012 · PUBLISHED 2024 · DOI: 10.1177/09731296241243129

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Skin moisture management is important for maintaining healthy skin and treating inflammatory skin diseases, and skin barrier function can be assessed by measuring trans-epidermal water loss (TEWL) and skin moisture content. Aim: This study was designed to investigate the effects of a topical cream containing 17% herbal extract (Cream17) on skin barrier function. Materials and Methods: In this study, the ability of investigational product (IP) to improve skin barrier function was investigated in 33 subjects using a randomized and assessor-blinded four-week clinical trial. In our study, the effects of IP on TEWL, skin water content, and the degree of itching were investigated. Results: After four weeks of application, TEWL was significantly reduced by IP (p < 0.001), and skin water content was significantly increased (p < 0.001) compared to non-treated control. In addition, topical application of IP significantly lowered the visual analog scale at the second and fourth weeks after treatment commencement as compared with those in the untreated control group (visit 3 at the second week, p < 0.05; visit 4 at the fourth week, p < 0.001). Conclusion: These results indicate that Cream17 can improve the skin barrier function, which is important for managing dry skin conditions such as atopic dermatitis.

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      Lyu, J., Kim, S., Kwon, K., Kim, Y., Choi, C., Jeong, H., & Kim, H. (2024). The Beneficial Effects of Topical Cream Containing 17% of Herbal Extract on Skin Barrier Function: A Randomized Four-week Trial. Pharmacognosy Magazine, 20(3), 1005–1012. https://doi.org/10.1177/09731296241243129