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    Traditional Chinese Medicine Offers New Ideas for the Treatment of Osteoporosis Through Multi-method Interventions in Ferroptosis

    Weikang Sun1, Zichen Shao1, Qipeng Yuan1, Huanan Li1,2★★ Corresponding author

    1. 1Graduate College, Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi, CHINA.
    2. 2Department of Scientific Research, Hospital Affiliated to Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi, China.

    CORRESPONDENCE

    Huanan Li

    Graduate College, Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi, CHINA.

    lihuanan1974@126.com

    Received: 21-08-2023; Accepted: 28-11-2023.

    Volume 20, Issue 3 · pp. 704–711 · PUBLISHED 2024 · DOI: 10.1177/09731296231221610

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Osteoporosis, a chronic metabolic bone disease, has a serious impact on the quality of life of postmenopausal women and elderly men. Its prevalence is on the rise as the population ages worldwide. There are many drawbacks to the current clinical approaches to treatment, and traditional chinese medicine (TCM) has long had a unique advantage in the prevention and treatment of osteoporosis. As research in the field of ferroptosis continues to intensify, the study of TCM has become a hot area in the treatment of the disease through multimethod interventions for ferroptosis. Based on this, this study searched the Cochrane Library, PubMed, Embase, CBM, CNKI, WanFang Data, and VIP databases using osteoporosis, TCM, and ferroptosis as keywords. Up to April 2023, research literature on the relationship between TCM, osteoporosis, and ferroptosis was collected. The results found a strong relationship between the main regulatory mechanisms of ferroptosis and osteoporosis. TCM methods with good therapeutic effects on osteoporosis, such as Zanthoxylum bungeanum, Curcumae longae, Salvia miltiorrhiza, Astragalus membranaceus, Bushen Huanjing Recipe, and external treatment of TCM, can all achieve interventions on ferroptosis under different pathways. It provides a new theoretical basis and research direction for the future treatment of osteoporosis through multiple methods of TCM to intervene in ferroptosis. Traditional Chinese Medicine, chinese herbal medicine, osteoporosis, ferroptosis, osteoblasts, osteoclasts

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      Sun, W., Shao, Z., Yuan, Q., & Li, H. (2024). Traditional Chinese Medicine Offers New Ideas for the Treatment of Osteoporosis Through Multi-method Interventions in Ferroptosis. Pharmacognosy Magazine, 20(3), 704–711. https://doi.org/10.1177/09731296231221610