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    Review

    Applications and Mechanisms of Taohong Siwu Decoction in the Treatment of Ischemic Stroke

    Runjia Liu1, Yanqing Li1, Xiaochen Zhang1, Kaixuan Tang1, Jiatong Li1, Tianhe Fang1, Xuanhe Tian1, Bingbing Han1,2★★ Corresponding author

    1. 1Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
    2. 2Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China

    CORRESPONDENCE

    Bingbing Han

    Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, No. 4655, University Road, Changqing District, Jinan, Shandong 250355, China.

    sumusu@163.com

    Received: 01-09-2023; Accepted: 06-02-2024.

    Volume 20, Issue 4 · pp. 1071–1085 · PUBLISHED 2024 · DOI: 10.1177/09731296241235435

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Ischemic stroke is a kind of sudden vascular disease of the brain brought on by ischemic hypoxic necrosis of the brain tissue which is becoming a significant global source of death and long-term impairment. Present common treatment options for cerebral ischemia including thrombolytic therapy, mechanical embolization, and intracranial arterioplasty can only benefit a few patients due to the narrow therapeutic time windows. Traditional Chinese Medicine (TCM) prescriptions possess the qualities of multi-ingredients, multi-targets, synergistic and multi-efficacy advantages as a means of treating ischemic stroke. Taohong Siwu Decoction (THSWD) is a famous TCM prescription that promotes blood flow, removes blood clots, adds nourishment, and tonifies blood. Clinical and laboratory research results show the significant advantages of THSWD in ischemic stroke treatment. This review summarizes THSWD’s natural materials and processing methods, pharmacological effects, and related mechanisms to treat ischemic stroke. Its mechanism of action focuses on improving hemorheology, anti-inflammatory response, reducing excitotoxicity, anti-calcium overload, anti-oxidative stress, etc. Moreover, we systematically summarize THSWD and its use in combination with other treatments. Finally, the research obstacles of THSWD in the treatment of ischemic stroke are summarized, and the application prospects in the medical field are prospected.

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      Liu, R., Li, Y., Zhang, X., Tang, K., Li, J., Fang, T., Tian, X., & Han, B. (2024). Applications and Mechanisms of Taohong Siwu Decoction in the Treatment of Ischemic Stroke. Pharmacognosy Magazine, 20(4), 1071–1085. https://doi.org/10.1177/09731296241235435