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    Article

    Schisandrol A Relaxes the Rat Trachea Via L-Type Ca2+ Channels and KV Channels

    Zhiying Xu1, Chengcheng Lin2, Jinghui Sun2, He Li2, Wenyue Zhuang3, Jianguang Chen2, Chunmei Wang2★, Haili Wang4★★ Corresponding author

    1. 1Department of Pharmacy, Affiliated Hospital, Beihua University, Jilin City, Jilin Province, China
    2. 2Department of Pharmacology, School of Pharmacy, Beihua University, Jilin City, Jilin Province, China
    3. 3Department of Molecular Biology, School of Laboratory Medicine, Beihua University, Jilin City, Jilin Province, China
    4. 4Department of Hepatology, Affiliated Hospital, Beihua University, Jilin City, Jilin Province, China

    CORRESPONDENCE

    Chunmei Wang

    s: Chunmei Wang, Department of Pharmacology, School of Pharmacy, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin City, Jilin Province 132013, China. ; Haili Wang, Department of Hepatology, Affiliated Hospital, Beihua University, No. 12 Jiefang Road, Chuanying District, Jilin City, Jilin Province 132002, China. Email: whl9750@126.com

    wangcm74@126.com

    Received: 04-11-2023; Accepted: 20-04-2024.

    Volume 20, Issue 4 · pp. 1237–1247 · PUBLISHED 2024 · DOI: 10.1177/09731296241253896

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Schisandra chinensis is widely applied in the prevention and treatment of asthma in China, but the material basis for the anti-asthmatic effect of S. chinensis is unclear. Our previous studies found that the lignans from S. chinensis can relax tracheal smooth muscle in rats. Schisandrol A (SCA) is a representative monomer of S. chinensis lignans with high content and activity. Purpose: This study was aimed at further exploring the relaxation effect of SCA and its mechanism on the isolated tracheal smooth muscle of rats through tracheal perfusion experiments. Materials and Methods: The isolated rat tracheal ring was precontracted with acetylcholine (ACh). Then, the impact of SCA on the tension of precontracted tracheal ring was studied. Verapamil (L-type calcium channel blocker) and four potassium channel blockers, including glibenclamide, tetraethylamine, 4-aminopyridine (4-AP), and barium chloride (BaCl2), as well as propranolol (β-adrenergic receptor antagonist), were respectively used to precontract the tracheal ring for investigation. Results: SCA could dose-dependently reduce the ACh-induced contraction of the tracheal ring, and the verapamil and 4-AP could weaken this effect, while BaCl2, glibenclamide, tetraethylamine, and propranolol did not show this effect. Conclusion: SCA can significantly relax the effect of tracheal smooth muscle of rats, and the underlying mechanism might be involved in the blocking of L-type Ca2+ channels and activating the voltage-dependent potassium channels (KV).

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      Xu, Z., Lin, C., Sun, J., Li, H., Zhuang, W., Chen, J., Wang, C., & Wang, H. (2024). Schisandrol A Relaxes the Rat Trachea Via L-Type Ca2+ Channels and KV Channels. Pharmacognosy Magazine, 20(4), 1237–1247. https://doi.org/10.1177/09731296241253896