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    Regulations of Immune Response by Astragalus in Animal Asthma Models: A Meta-analysis

    Song Wang1, Xinhua Chen2, Zuoqiao Shi3, Qianqian Shen4, Jing Li5, Wang Hua1, Wang Shujing1, Wanjing Wu3, Qing Xi3, Guowen Li3★★ Corresponding author

    1. 1Department of Scientific Research Management, Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai, China.
    2. 2Department of Traditional Chinese Medicine, Jinshan Hospital of Fudan University, Shanghai, China.
    3. 3Department of Pharmacy, Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai, China.
    4. 4School of Public Health, Shanghai University of TCM, Shanghai, China.
    5. 5Department of Teaching Management, Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai, China.

    CORRESPONDENCE

    Guowen Li

    Department of Pharmacy, Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai, China.

    lgwshutcm@163.com

    Received: 15-01-2024; Accepted: 18-07-2024.

    Volume 21, Issue 2 · pp. 380–393 · PUBLISHED 2025 · DOI: 10.1177/09731296241276582

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Asthma is a chronic respiratory condition by airway inflammation. Traditional Chinese Medicine, is commonly used to treat it. Astragalus is known for its immunoregulation, anti-inflammatory, and antioxidant effects. Objectives: To systematically evaluate the efficacy of Astragalus in asthma animal models using meta-analysis methods. Methodology: A systematic search was performed in various databases, such as China National Knowledge Infrastructure (CNKI), WanFang Data, PubMed, Web of Science, and Cochrane Library databases for animal studies on Astragalus intervention in asthma models, with the search period extending up to September 2023. Two researchers performed independent literature screening and data extraction. The quality of the included studies was assessed by the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) animal experiment bias risk assessment tool. Meta-analysis was performed with RevMan (version 3.6.1). Results: A total of 25 experiments were included. Meta-analysis indicated that Astragalus can significantly reduce total leukocytes, neutrophils, lymphocytes, and eosinophils in animal models of asthma. It also downregulated the expression levels of interleukin-4 and interleukin-5, while upregulation of interferon-γ and interleukin-10 expression was observed; however, the impact on macrophages was found to be not statistically significant (p > 0.05). Conclusion: Our systemic review suggested the potential efficiency of Astragalus in asthma treatment in China, although its mechanism is still unclear. The functions of Astragalus may be associated with attenuating airway inflammation through the regulation of immune response.

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      Wang, S., Chen, X., Shi, Z., Shen, Q., Li, J., Hua, W., Shujing, W., Wu, W., Xi, Q., & Li, G. (2025). Regulations of Immune Response by Astragalus in Animal Asthma Models: A Meta-analysis. Pharmacognosy Magazine, 21(2), 380–393. https://doi.org/10.1177/09731296241276582