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    Tomatidine, A Promising Steroidal Alkaloid Alleviates Various Noxious Stimuli Induced Nociception in Mice Model

    Jiajia Chen1, Xi Wang2, Dan Wang1, Hengming Yin3, Guoping Ma4★★ Corresponding author

    1. 1Pharmaceutical Department, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, Hubei, CHINA.
    2. 2Department of Anesthesiology, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, CHINA.
    3. 3Department of Anesthesiology, Qinghai Provincial People’s Hospital, Xining, Qinghai, CHINA.
    4. 4Department of Anesthesiology, Shanghai Traditional Chinese MedicineIntegrated Hospital, The Affiliated Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, CHINA.

    CORRESPONDENCE

    Guoping Ma

    Department of Anesthesiology, Shanghai Traditional Chinese MedicineIntegrated Hospital, The Affiliated Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, CHINA.

    gpmshiyan126@outlook.com

    Received: 05-06-2024; Accepted: 14-10-2024.

    Volume 21, Issue 3 · pp. 1077–1089 · PUBLISHED 2025 · DOI: 10.1177/09731296241307746

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Nociception, often described as the body’s ability to sense and respond to harmful stimuli, represents a global discomfort that profoundly impacts individuals across the globe. It functions as a fundamental warning process, alerting organisms against potential threats and promoting protective behaviors. However, when dysregulated or chronic, nociception can become a significant burden, leading to persistent pain and diminished quality of life. Various analgesic drugs play a crucial role in alleviating pain and improving the quality of life for millions of people worldwide. While analgesic drugs provide significant relief for acute and chronic pain conditions, they can cause side effects ranging from mild gastrointestinal disturbances, drowsiness, and constipation to major complications such as cardiovascular damage and nephrotoxicity. Objectives: Hence, we investigated the potency of a phytochemical tomatidine against various noxious stimuli-induced nociception. Materials and Methods: Tomatidine pain-relieving potency has been assessed against heat stimuli and chemical-induced visceral pain. The neuropathic pain-relieving potency of tomatidine was examined with glutamate and capsaicin-induced mice models. Results: Tomatidine potency against intense pain was examined with a formalin-induced biphasic nociception model. Carrageenan induced an inflammatory response, peritoneal leukocyte infiltration, and air pouch model were performed to analyze the anti-inflammatory effect of tomatidine against inflammatory cytokines-induced nociception. The antisedative potency of tomatidine was confirmed with open-field test analysis. Our results confirm that tomatidine effectively inhibited nociception induced by thermal and chemical stimuli. It also alleviates the inflammatory cytokines stimulated pain and does not render any sedative effect in mice models. Conclusion: To conclude tomatidine is a potent nonsedative antinociceptive drug that can be formulated as an analgesic.

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      Chen, J., Wang, X., Wang, D., Yin, H., & Ma, G. (2025). Tomatidine, A Promising Steroidal Alkaloid Alleviates Various Noxious Stimuli Induced Nociception in Mice Model. Pharmacognosy Magazine, 21(3), 1077–1089. https://doi.org/10.1177/09731296241307746