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    Article

    Cardioprotective Potential of Bioactive Compound from Methanolic Extract of Asparagus racemosus: An in silico Study Utilizing GC–MS Analysis

    Sandip Sen1, Biswabara Roy1, N. Kannappan2, Khalid Zoghebi3, Mohammed Albratty3, Hassan A. Alhazmi3,4,5, Asim Najmi3, Md Shamsher Alam3★★ Corresponding author

    1. 1School of Pharmacy, Guru Nanak Institutions Technical Campus, Ibrahimpatnam, Hyderabad, Telangana, INDIA.
    2. 2Department of Pharmacy, Faculty of Engineering & Technology, Annamalai University, Annamalai Nagar, Tamil Nadu, INDIA.
    3. 3Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA.
    4. 4Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, SAUDI ARABIA.
    5. 5Medical Research Center, Jazan University, Jazan, Saudi Arabia Corresponding authors: Md Shamsher Alam, Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia. E-mail: mosalam@jazanu.edu.sa Sandip Sen, School of Pharmacy, Guru Nanak Institutions Technical Campus, Ibrahimpatnam, Hyderabad, Telangana 501506, India. E-mail: sandipsen2010@gmail.com.

    CORRESPONDENCE

    Md Shamsher Alam

    Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA.

    mosalam@jazanu.edu.sa

    Received: 14-05-2024; Accepted: 23-10-2024.

    Volume 21, Issue 3 · pp. 1100–1113 · PUBLISHED 2025 · DOI: 10.1177/09731296241300873

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Historical accounts suggest that, throughout antiquity, medicinal plants and their constituent parts have been used to treat a variety of ailments. Asparagus racemosus, this plant exhibits a wide range of potential uses in medicine. Objectives: The purpose of this study is to identify any potentially bioactive ingredients in the methanolic extract of A. racemosus. Materials and Methods: A variety of compounds were detected using gas chromatography, and their molecular structures were confirmed by Fourier transform infrared (FTIR) analysis and mass spectrometry. Using in silico approaches, the molecule’s potential as a therapeutic candidate, biological activity, and projected targets were carefully examined. Results: The molecule 4-(((9-(5-(ethylcarbamoyl)-3,4-dihydroxy tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)methyl)benzoic acid was found in the highest concentration (27.37%). The identified molecule is purine alkaloid in nature. The promising drug-like properties and therapeutic efficacy for the investigated molecule. Conclusion: It could serve as a viable therapeutic option for addressing cardiovascular disorders.

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      Sen, S., Roy, B., Kannappan, N., Zoghebi, K., Albratty, M., Alhazmi, H. A., Najmi, A., & Alam, M. S. (2025). Cardioprotective Potential of Bioactive Compound from Methanolic Extract of Asparagus racemosus: An in silico Study Utilizing GC–MS Analysis. Pharmacognosy Magazine, 21(3), 1100–1113. https://doi.org/10.1177/09731296241300873