Cedrin Mitigates Dyslipidemia, Inflammation, and Oxidative Stress in Streptozotocin-induced Diabetes Mellitus in Rats

ABSTRACT

Background: Cedrin is a major bioactive flavonoid compound present in the Cedrus deodara plant and has been reported to have several biological activities. Diabetes mellitus is an endocrine and metabolic disease marked by high blood sugar levels leading to reduced insulin production and/or decreased insulin efficacy. Hyperglycemia leads to chronic health complications and organ dysfunction, specifically affecting the nerves, blood vessels, kidneys, eyes, liver, and heart. Objectives: The aim of this work is to study the effect of cedrin on glycemic control, hyperlipidemia, liver function markers, and biochemical markers of streptozotocin (STZ)-induced diabetes in rats. Materials and Methods: The STZ was utilized to initiate diabetes in experimental rats, and after the onset of diabetes, the rats were treated with cedrin for 30 days. After the treatment periods, the experimental rats’ glucose levels, food and water uptake, and body and organ weights were assessed. The biochemical markers, including insulin, hexokinase, glycated hemoglobin, and so on, were investigated using diagnostic kits. The concentrations of oxidative marker levels, inflammatory cytokines, and lipid marker levels were assessed using diagnostic kits. Results: Cedrin treatment effectively mitigated the glucose level, food and water consumption, organ weights, and glycated hemoglobin (HbA1c) while increasing the body weight and hexokinase levels of the STZ-induced rats. In the STZ-induced rats, the cedrin treatment remarkably elevated the antioxidant levels, reduced oxidative stress biomarkers, and decreased the inflammatory cytokine levels in their serum. Conclusion: The current study demonstrates that cedrin treatment effectively regulated dyslipidemia, inflammatory response, and oxidative stress in rats with STZ-induced diabetes. Therefore, it can be a potential salutary agent to treat diabetes in the future.

KEYWORDS

• Diabetes mellitus
• hexokinase
• cedrin
• hyperlipidemia
• oxidative stress

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• DOI10.1177/09731296241297429Copy

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