Linarin Protects against Cisplatin-induced Nephrotoxicity via Subsiding Proinflammatory and Oxidative Stress Biomarkers in Male Wistar Rats

ABSTRACT

Background: One of the most effective anticancer medications for treating a range of cancers is cisplatin (Cis). Its use is limited because of its nephrotoxicity. Objectives: This study aims to evaluate the role of linarin (LIN) in protecting rats from Cis-induced nephrotoxicity. Materials and Methods: The animals were split up into four groups: Group I consisted of control animals; group II consisted of Cis-treated animals; group III consisted of Cis-treated animals that received a 25 mg/kg dosage of LIN; group IV consisted of Cis-treated animals that received a 50 mg/kg dose of LIN. We measured the kidney and body weights of each experimental group. Blood samples were taken to measure the blood urea nitrogen (BUN) and Cr levels in the test animals. To further evaluate the effects of LIN therapy in a dose-dependent manner, an investigation of antioxidant enzymes, oxidative stress indicators, plasma sodium and potassium levels, inflammatory markers, and histopathology was conducted. Results: We found that giving LIN to Cis-treated rats helped to enhance renal function. The animals’ body weight, histopathological conditions, and amount of antioxidant enzymes were all markedly elevated by LIN in the animals. Additionally, it decreased kidney weight, BUN and Cr levels, oxidative stress indicators, and inflammatory markers. Conclusion: Therefore, we conclude that LIN can be utilized to protect the kidneys from damage caused by Cis therapy. Nurses can promote well-being and recovery in patients at risk of Cis-induced nephrotoxicity by encouraging gentle physical activities and providing emotional and psychological support, leveraging LIN’s protective effects.

KEYWORDS

• Linarin
• cisplatin
• oxidative stress markers
• kidney

Showing references and in-text citations exactly as published.

• DOI10.1177/09731296241297432Copy

RELATED ARTICLES

Matched on section and article type within this issue of Pharmacogn. Mag..

• Article · VOLUME 21, ISSUE 3Bioflavonoid Tangeretin regulates RANK/RANKL/OPG Signaling Proteins via Stimulating Estrogenic Activity in Ovariectomized RatsWeike Tian, Wei Zhang, Li Chen, Junlei Liao, Xuesong Yang · pp. 1001–1012Original Research ArticleSame type: Article
• Article · VOLUME 21, ISSUE 3PhcogMag 21 3 1013Yanhong Zhang, Yanlong He · pp. 1013–1021Original Research ArticleSame type: Article
• Article · VOLUME 21, ISSUE 3Rosmanol Effectively Prevents Diethylnitrosamine-induced Hepatocellular Carcinoma in Rats by Regulating the PI3K/Akt Signaling PathwayWei Cao, Qi Liu, Ying Wang, Lianfeng Chen · pp. 1022–1033Original Research ArticleSame type: Article
• Article · VOLUME 21, ISSUE 3Liquiritin Promotes Vasodilation Effects by Activating the Kv and KATP Channels in the Isolated Rat Thoracic AortaMengXue Ma, YouLan Che, Xin Yang, Zhi Wang, Ya Wen Bai, Yang Yu, QingBin Xu, Ru Zhou · pp. 1034–1042Original Research ArticleSame type: Article