Research Progress on Reproductive Toxicity and Reversibility of Tripterygium wilfordii Based on Gender Differences
Wang Jinjin1, Jin De1, Zhu Qin1★★ Corresponding author
- 1Department of Nephrology, Organization Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, CHINA.
CORRESPONDENCE
Zhu Qin
Department of Nephrology, Organization Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, CHINA.
Received: 10-06-2024; Accepted: 17-12-2024.
Volume 21, Issue 4 · pp. 1139–1152 · PUBLISHED 2025 · DOI: 10.1177/09731296251313623
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ABSTRACT
Tripterygium wilfordii Hook F. (TwHF), a member of the Celastraceae family and belonging to the genus Tripterygium, is a vine-like shrub. It contains numerous active components, such as Tripterygium glycosides (GTW) and triptolide (TP), widely known for their significant reproductive toxicity. This toxicity is characterized by its detrimental effects on the testes and ovaries, leading to reduced libido, apoptosis of germ and follicle cells, and abnormal secretion of sex hormones. Thus, it is necessary to explore the mechanisms behind TwHF’s reproductive toxicity, which will lead to advancements in detoxification and efficacy enhancement strategies. This article offers a comprehensive overview and analysis of the research conducted on reproductive toxicity and its reversibility induced by TwHF, aiming to provide a reference for its rational use in clinical settings.
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Jinjin, W., De, J., & Qin, Z. (2025). Research Progress on Reproductive Toxicity and Reversibility of Tripterygium wilfordii Based on Gender Differences. Pharmacognosy Magazine, 21(4), 1139–1152. https://doi.org/10.1177/09731296251313623