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    Article

    Study on the Neuroprotective Mechanism of Salidroside Modified with Polydopamine Nanoparticles in Regulating Notch Pathway by Inhibiting miR-155 in Stroke Rats

    activity of AQP4, TLR TLR4, Song Liu1, Xiaomeng Lv1, Dong Wang1★★ Corresponding author

    1. 1Department of Neurosurgery, Dongping People’s Hospital, Tai’an, Shandong, CHINA.

    CORRESPONDENCE

    Dong Wang

    Department of Neurosurgery, Dongping People’s Hospital, Tai’an, Shandong, CHINA.

    13853873429@163.com

    Received: 01-04-2024; Accepted: 31-07-2024.

    Volume 21, Issue 4 · pp. 1176–1186 · PUBLISHED 2025 · DOI: 10.1177/09731296241282387

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background and Objectives: Stroke threatens neurological function. Salidroside is widely used to treat neurological diseases such as stroke. Previous studies have shown that miR-155 plays an important regulatory role in the pathogenesis of stroke and that the Notch pathway plays an important role in nervous system development and regeneration. Materials and Methods: PDA NPs-SAL complex was prepared, a stroke rat model was constructed, and the cerebral infarction area of rats was measured. Analyze the changes of PDA NPs-SAL on rat brain tissue and evaluate the neuroprotective effect. Detect the changes in miR-155 and Notch pathway-related proteins in stroke rat models to further understand the role of miR-155 and Notch pathway in the pathogenesis of stroke and their relationship. Results: Salidroside had certain protective effects on the nerves of stroke rats, and the effect of PDA NPs-SAL was more prominent. At the same time, PDA NPs-SAL promotes the Notch pathway by inhibiting miR-155, thereby exerting a neuroprotective effect on stroke rats. Conclusion: Under the intervention of PDA NPs-SAL, the neurological function scores of rats were reduced, and the effect of PDA NPs-SAL was more significant. In addition, PDA NPs-SAL inhibited miR-155 and activated the Notch pathway, thereby reducing the water content of rat brain tissue and cerebral infarction area, thereby exerting a neuroprotective effect on stroke rats.

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      AQP, A. O., TLR, T., Liu, S., Lv, X., & Wang, D. (2025). Study on the Neuroprotective Mechanism of Salidroside Modified with Polydopamine Nanoparticles in Regulating Notch Pathway by Inhibiting miR-155 in Stroke Rats. Pharmacognosy Magazine, 21(4), 1176–1186. https://doi.org/10.1177/09731296241282387