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    Artemetin Inhibits Cell Growth and Activates Caspase-dependent Apoptotic Cell Death Colon Cancer HCT-116 Cells

    Yan Chen1, Lu Men1★★ Corresponding author

    1. 1Department of Gastroenterology, Affiliated Hospital of Hebei University, Baoding, Hebei, CHINA.

    CORRESPONDENCE

    Lu Men

    Department of Gastroenterology, Affiliated Hospital of Hebei University, Baoding, Hebei, CHINA.

    lumen000918@outlook.com

    Received: 18-12-2024; Revised: 22-01-2025; Accepted: 13-03-2025.

    Volume 21, Issue 4 · pp. 1212–1219 · PUBLISHED 2025 · DOI: 10.1177/09731296251331682

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Colon cancer, a prevalent form of gastrointestinal malignancy, poses a significant public health issue globally. The onset of colon cancer is a complex mechanism implicating genetic and environmental factors, including dietary habits and lifestyle choices. Objectives: The current study was undertaken to investigate the anti-tumor effects of artemetin against colon cancer cells. Materials and Methods: The influence of artemetin on the proliferation of HCT-116 cells was evaluated with an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) test. Also, the extent of apoptosis in both untreated and artemetin-exposed HCT-116 cells was studied using a dual staining technique. The activities of the caspase enzymes (caspase-3, -8, and -9) in both untreated and artemetin-exposed HCT-116 cells were evaluated using a commercial diagnostic kit. Results: The administration of several dosages of artemetin significantly suppressed the HCT-116 cells dose-dependently. Furthermore, artemetin treatment significantly induced apoptosis in HCT-116 cells, which is evidenced by dual staining assay. Artemetin treatment also elevated the caspase-3, -8, and -9 activities in the colon cancer cells. Conclusion: The present study revealed that artemetin possesses anti-cancer activities against colon cancer, reducing cell viability and inducing caspase-mediated apoptosis in HCT-116 cells. Consequently, the present findings indicate artemetin as a favorable anti-tumor candidate for future colon cancer therapy.

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      Chen, Y., & Men, L. (2025). Artemetin Inhibits Cell Growth and Activates Caspase-dependent Apoptotic Cell Death Colon Cancer HCT-116 Cells. Pharmacognosy Magazine, 21(4), 1212–1219. https://doi.org/10.1177/09731296251331682