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    Article

    Antinociceptive and Anti-inflammatory Activities of Alstonia scholaris Linn. R.br.,

    Arulmozhi S1★, Papiya Mitra Mazumder2, Purnima Ashok1, Basavaraj Hulkoti1, L.Sathiya Narayanan3★ Corresponding author

    1. 1Department of Pharmacology, K.L.E.S’s College of Pharmacy, II Block, Rajaji Nagar, Bangalore-560 010. Karnataka, India.
    2. 2Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand – 835 215, India.
    3. 3Department of Pharmaceutical Chemistry, The Oxford College of Pharmacy, Bangalore – 560 078, India.

    CORRESPONDENCE

    Arulmozhi S

    Arulmozhi.S,Department of Pharmacology, K.L.E.S’s College of Pharmacy, II Block, Rajaji Nagar, Bangalore-560 010. Karnataka, India.

    pharmarul@gmail.com

    Volume 3, Issue 10 · pp. 106–107 · PUBLISHED 2007 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Alstonia scholaris linn. (apocynaceae) is traditionally used as an antinociceptive and anti-inflammatory agent. The objective of this study was to investigate experimentally the possible antinociceptive and anti-inflammatory properties of alstonia scholaris. The effect of ethanolic extract of leaves of alstonia scholaris (EEAS) was evaluated in experimental models of pain and inflammation. The leaf extract at 200 and 400 mg/kg showed significant decrease in acetic acid induced writhings in mice with a maximum of 65.76 % at 400 mg/kg. in hot plate method, the percentage of pain inhibition was found to be 73.90 % and 79.56 % with 200, 400 mg/kg of EEAS respectively. There was a significant (p<0.001) inhibition in carrageenan induced paw edema with EEAS 200 and 400 mg/kg. The anti-inflammatory effects observed with the extract were comparable to that of standard. There was a significant antiulcerogenic property. The present study indicates that the ethanolic extract of alstonia scholaris exhibit significant antinociceptive, anti-inflammatory and antiulcerogenic activities.

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      S, A., Mazumder, P. M., Ashok, P., Hulkoti, B., & Narayanan, L. (2007). Antinociceptive and Anti-inflammatory Activities of Alstonia scholaris Linn. R.br.,. Pharmacognosy Magazine, 3(10), 106–107.