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    Determination of topical anti-inflammatory activity of the essential oil and extracts of Lippia alba (Mill.) N.E. Brown (Verbenaceae), using the model of mouse ear edema induced by TPA and AA

    B. Badilla1★, J. Cambronero2, J. F. Cicció3, T. Cordero3, G. Mora3★ Corresponding author

    1. 1Instituto de Investigación en Ciencias Farmacéuticas (INIFAR), Facultad de Farmacia. Universidad de Costa Rica. 2060 San José, Costa Rica.
    2. 2Centro de Investigaciones en Productos Naturales (CIPRONA) y Escuela de Química, Universidad de Costa Rica, 2060 San José, Costa Rica.
    3. 3Centro de Investigaciones en Productos Naturales (CIPRONA). Investigador Asociado (jubilado).

    CORRESPONDENCE

    B. Badilla

    Instituto de Investigación en Ciencias Farmacéuticas (INIFAR), Facultad de Farmacia. Universidad de Costa Rica. 2060 San José, Costa Rica.

    bbadilla@cariari.ucr.ac.cr

    Volume 3, Issue 11 · pp. 139–140 · PUBLISHED 2007 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    The topical anti-inflammatory properties of hydro-alcoholic and diethyl ether extracts, as well as the pure essential oil of Lippia alba (Mill.) N.E. Brown (Verbenaceae), were studied. The mouse ear-inflammation-induction model was applied, using 12-O-tetradecanoylphorbol-13-acetate (TPA) and arachidonic acid (AA) as flogistic agents. Both hydro-alcoholic and diethyl ether extracts of L. alba, as well as the essential oil, showed topical anti-inflammatory activity. Topical administration of the essential oil showed a significant amount of anti-inflammatory activity in the TPA induced ear edema model and a lower potency in the AA induced edema. The anti-inflammatory effect of the hydro-alcoholic and diethyl ether extracts was best observed in the mouse ear edema model induced by AA (79.51% and 74.92% of inflammation respectively). The major components of the essential oil of the leaves are carvone (67.9%) and limonene (26.8%).

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      Badilla, B., Cambronero, J., Cicció, J. F., Cordero, T., & Mora, G. (2007). Determination of topical anti-inflammatory activity of the essential oil and extracts of Lippia alba (Mill.) N.E. Brown (Verbenaceae), using the model of mouse ear edema induced by TPA and AA. Pharmacognosy Magazine, 3(11), 139–140.