Effect of Terminalia chebula on monoamine oxidase and antioxidant enzyme activities in aged rat brain
R. Mahesh1, T. Ramesh2, KR. Nagulendran2, S. Velavan2, V. Hazeena Begum2★★ Corresponding author
- 1Department of Siddha Medicine, Faculty of Science, Tamil University, Vakaiyur, Thanjavur 613 005, Tamilnadu, India.
- 2Department of Pharmacology, Kyung Hee University, Seoul, Korea 130-701, Korea.
CORRESPONDENCE
V. Hazeena Begum
Department of Pharmacology, Kyung Hee University, Seoul, Korea 130-701, Korea.
Volume 3, Issue 12 · pp. 240–241 · PUBLISHED 2007 · DOI:
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ABSTRACT
The aging presents itself with various alterations in physiological events. The free radical theory of aging reflects the free radical induced damage to cellular components and increases in catecholamine metabolism in aging. Activities of MAO-B, MDA, MnSOD, CAT were showed a significant increase and decrease in the activity of GPx in brain mitochondria of aged rats as compared to young control rats. Administration of Terminalia chebula aqueous extract 200mg/kg body weight orally for 4 weeks to aged rats showed a marked decrease in the activities of brain MAO-B, MDA, MnSOD, CAT activities and significant increase in the activity of GPx. T.chebula could prevent MAO-B induced oxidation and lipid peroxidation in the brain of aged rats. Thus the present study revealed that the antioxidant potential of T. chebula by protecting the brain cells against free radical toxicity through the inhibitory action on catecholamine oxidation and lipid peroxidation in aged rats and modulating antioxidant defense systems.
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Mahesh, R., Ramesh, T., Nagulendran, K., Velavan, S., & Begum, V. H. (2007). Effect of Terminalia chebula on monoamine oxidase and antioxidant enzyme activities in aged rat brain. Pharmacognosy Magazine, 3(12), 240–241.