Formulation, Excipient Properties and Pharmacological Activities of Catechin Liposomes
Shiny Ganji1, Jithan Aukunuru1★★ Corresponding author
- 1Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal, AP, India-506001, India.
CORRESPONDENCE
Jithan Aukunuru
Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal, AP, India-506001, India.
Volume 4, Issue 13 · pp. 121–122 · PUBLISHED 2008 · DOI:
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ABSTRACT
Liposomes containing catechin were prepared using soya lecithin by thin film hydration technique. The entrapped vesicles were characterized for their shape, size, drug entrapment efficiency and in vitro release rate. Excipient properties were observed using curcuminoids. The liposomal formulation was able to protect the curcuminoid solution from degradation to some extent. The resulting formulation was evaluated for antioxidant activity in vitro and screened for hepatoprotective activity against carbon tetrachloride induced toxicity and antidiabetic activity against alloxan induced diabetes in vivo. The present study revealed that catechin liposomes showed good antioxidant property similar to ascorbic acid but failed to show hepatoprotective and antihyperglycemic activity with the selected doses.
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Ganji, S., & Aukunuru, J. (2008). Formulation, Excipient Properties and Pharmacological Activities of Catechin Liposomes. Pharmacognosy Magazine, 4(13), 121–122.