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    Article

    Microvascular protective activity of anthocyanosides-rich extract from Acalypha langiana

    Rosa Martha Perez Gutierrez1★, Rosario Vargas Solis2★ Corresponding author

    1. 1Laboratorio de Investigacion de Productos Naturales. Escuela Superior de Ingeniería Química e Industias extractivas IPN. Punto fijo 16, col. Torres Lindavista cp 07708, México D.F. México, México.
    2. 2Laboratorio de Investigación de Fitofarmacología. Universidad Autónoma Metropolitana-Xochimilco A.P. 23-181 Mexico D.F, Mexico.

    CORRESPONDENCE

    Rosa Martha Perez Gutierrez

    Laboratorio de Investigacion de Productos Naturales. Escuela Superior de Ingeniería Química e Industias extractivas IPN. Punto fijo 16, col. Torres Lindavista cp 07708, México D.F. México, México.

    rmpg@prodigy.net.mx

    Volume 4, Issue 14 · pp. 85–86 · PUBLISHED 2008 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    A mixture of anthocyanosides from the leaves of Acalypha langiana consisting of cyanidin-3-glucoside, cyanidin-3-rutinoside, peonidin-3-galactoside, petunidin-3-glucoside, delphinidin-3-glucoside, malvidin-3-glucoside, malvidin-5,5-diglucoside and the anthocyanidin pelargonidin, were characterised by means of HPLC and UV-VIS. Phenolic components were extracted with pure methanol. The samples were diluted in the mixture of methanol and formic acid just before the injection on the column and separated on Hypersil PEP 300 C18 chromatographic column using gradient solvent system consisting of formic acid, water and methanol. DAD detector was employed at 520 nm for anthocyanins. An Acalypha langiana anthocyanosides preparation (equivalent to 30% of anthocyanidins) demonstrated significant vasoprotective in rabbits, the skin capillary permeability increase, due to chloroform, was reduced after i.p. (25-100 mg/kg) anthocyanosides. Comparison was made between the action of the methanol extract and a known protective microvascular drug as troxerutin (25 mg/kg). The mixed of anthocyanosides was more active that the troxerutin.

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      Gutierrez, R. M. P., & Solis, R. V. (2008). Microvascular protective activity of anthocyanosides-rich extract from Acalypha langiana. Pharmacognosy Magazine, 4(14), 85–86.