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    Article

    Phytophenolics from Peltophorum africanum Sond. (Fabaceae) with promising hepatoprotective activity

    Sherif S. Ebada1, Nahla A. Ayoub1★, Abdel Nasser B. Singab1, Mohamed M. Al-Azizi1★ Corresponding author

    1. 1Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbasia, Cairo, Egypt.

    CORRESPONDENCE

    Nahla A. Ayoub

    Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbasia, Cairo, Egypt.

    ayoub.n@link.net

    Volume 4, Issue 16 · pp. 287–288 · PUBLISHED 2008 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    The aqueous alcoholic extract of Peltophorum africanum Sond. (Fabaceae) exhibited hepatoprotective activity represented by significant reduction of elevated serum liver enzymes and significant reduction in hepatic TBARS levels in hepatotoxicated animals. Fifteen known phenolic metabolites were identified for the first time from the entitled plant. Establishment of all structures were based on conventional methods of analysis, ESI/MS, in addition, complete 1H and 13C NMR assignments were obtained for the isolated compounds. Their structures were elucidated to be; gallic acid 1, 3-O-methyl gallic acid 2, quercetin-3-O-1C4-α-L-rhamnopyranosyl-(1'''→6'')-4C1-β-D-glucopyranoside, rutin 3, kaempferol-3-O-1C4-α-L-rhamnopyranosyl-(1'''→6'')-4C1-β-D-glucopyranoside, nicotiflorin 4, kaempferol-3-O-4C1-β-D-glucoside, astralagin 5, quercetin-3-O-4C1-β-D-glucoside, isoquercitrin 6, methyl 3,4,5-trihydroxybenzoate, methyl gallate 7, kaempferol-3-O-(6''-O-galloyl)-4C1-β-D-galactopyranoside 8, quercetin-3-O-(6''-O-galloyl)-4C1-β-D-galactopyranoside 9, myricetin-3-O-(6''-O-galloyl)-4C1-β-D-galactopyranoside 10, (-)-epigallocatechin-3-O-gallate 11, (+)-gallocatechin-3-O-gallate 12, myricetin 13, quercetin 14, kaempferol 15.

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      Ebada, S. S., Ayoub, N. A., Singab, A. N. B., & Al-Azizi, M. M. (2008). Phytophenolics from Peltophorum africanum Sond. (Fabaceae) with promising hepatoprotective activity. Pharmacognosy Magazine, 4(16), 287–288.