Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Antioxidant, antimicrobial and cytotoxicity properties of the methanolic extract from Grewia tiliaefolia Vahl

    Yadav Vivek Ramshankar1★, Pandit Vinaya1, P. Vijayan2★ Corresponding author

    1. 1Department of Pharmaceutics, Al-Ameen College of Pharmacy, Hosur Road, Bangalore – 560027.
    2. 2Department of Pharmaceutical Biotechnology, J.S.S. College of Pharmacy, Rockland, Ooty.

    CORRESPONDENCE

    Yadav Vivek Ramshankar

    Department of Pharmaceutics, Al-Ameen College of Pharmacy, Hosur Road, Bangalore – 560027.

    vivekyadav78@yahoo.co.in

    Volume 4, Issue 16 · pp. 329–330 · PUBLISHED 2008 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    The whole, fresh barks of Grewia tiliaefolia Vahl. (Tiliiacea), were extracted with methanol. All obtained extracts were evaluated for their antioxidant, antimicrobial and cytotoxicity properties. Two different methods (disc diffusion and agar dilution methods) were employed to evaluate the antimicrobial activities of plant extracts against B. Sterarothermophilus, B. Aerogeuosa, B. Coagulans, K.Pneumoniae, L. Licjmani, Shigell and P. Cepacia. The minimum inhibitory concentration (MIC) values of Grewia tiliaefolia methanolic extract was found to be 125 µg/ml against B. Sterarothermophilus, 31.25 µg/ml against L. Licjmani and 62.5 µg/ml against P. Cepacia. The antioxidant potential was evaluated using following in vitro methods: Nitric oxide radical inhibition activity (superoxide anion) and scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. The antioxidant activities of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (13.65 µg/ml IC50 value) and superoxide anion radicals (44.0 µg/ml IC50 value) and reducing power. Cytotoxicity study was done using Vero and HEp-2 cell line. CTC50 values were found to be 205 ± 13.23 µg/ml and 345 ± 12.65 µg/ml. The results showed that Grewia tiliaefolia extract had great potential as antioxidant, antimicrobial and very good anticancer agent.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Ramshankar, Y. V., Vinaya, P., & Vijayan, P. (2008). Antioxidant, antimicrobial and cytotoxicity properties of the methanolic extract from Grewia tiliaefolia Vahl. Pharmacognosy Magazine, 4(16), 329–330.