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    Article

    Effects of ethanolic extract of pine needles (Pinus eldarica Medw.) on reserpine-induced depression-like behavior in male Wistar rats

    Samira Bolandghamat1, Ali Moghimi1★, Mehrdad Iranshahi2★ Corresponding author

    1. 1Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Iran.
    2. 2Biotechnology Research Center, and School of Pharmacy, Mashhad University of Medical Sciences, Iran.

    CORRESPONDENCE

    Ali Moghimi

    Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Iran.

    moghimi@um.ac.ir

    Received: 27-05-2010; Revised: 15-08-2010.

    Volume 7, Issue 27 · pp. 248–253 · PUBLISHED 25 August 2011 · DOI: 10.4103/0973-1296.84240

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: In this study, the antidepressant activity of ethanolic extract of Pinus eldarica Medw needles was assessed using forced swimming test (FST) in rats. Materials and Methods: Male Wistar rats were randomly divided into six Groups and treated as follows: first group was received only reserpine (6 mg/kg, i.p.), second group was received reserpine (6 mg/kg, i.p.) and imipramine (10 mg/kg, i.p.), three experimental groups received reserpine (6 mg/kg, i.p.) and three doses of pine needle extract (100, 300, and 500 mg/kg, p.o.) respectively and the final group (control group) received only vehicle (5% DMSO, i.p.). Results: Acute oral administration of ethanolic extract of P. eldarica Medw needles at a dosage of 300 mg/kg reduced reserpine- induced increase in immobility time in the FST, demonstrating an antidepressant effect in the FST. Additionally, extract treatment did not modify the ambulation and rearing evaluated in open field test, indicating that antidepressant effect found in the forced swimming test was not based on the stimulation of locomotor activity. Conclusion: These results indicate that ethanolic extract of Pinus eldarica needles possesses an antidepressant activity.

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      Bolandghamat, S., Moghimi, A., & Iranshahi, M. (2011). Effects of ethanolic extract of pine needles (Pinus eldarica Medw.) on reserpine-induced depression-like behavior in male Wistar rats. Pharmacognosy Magazine, 7(27), 248–253. https://doi.org/10.4103/0973-1296.84240