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    Article

    Anti-fatigue effects of Panax notoginseng in simulation plateau-condition mice

    Simin Zhou2,3,4, Yujie Wang3,4,5, Huaijun Tian2,3,4, Qingyuan Huang3,4,5, Yuqi Gao3,4,5, Gang Zhang2,3,4★★ Corresponding author

    1. 1Department of High Altitude Military Hygiene, College of High Altitude Military Medicine, Third Military Medical University, China.
    2. 2Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, China.
    3. 3The Key Laboratory of High Altitude Medicine, PLA, China.
    4. 4Department of Pathophysiology and High Altitude Physiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing- 400 038, China.

    CORRESPONDENCE

    Gang Zhang

    Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, China.

    zhanggang1968@yahoo.com.cn

    Received: 06-09-2011; Revised: 16-10-2011.

    Volume 8, Issue 31 · pp. 197–201 · PUBLISHED 2 August 2012 · DOI: 10.4103/0973-1296.99284

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Panax notoginseng (PN) is one of the most commonly used Chinese herbal drugs. Panax notoginseng saponins (PNS) is the main effective components of PN. However, the anti- fatigue effect of PNS in plateau-condition is unknown. Objective: Explore the anti-fatigue effects of PNS in mice living under simulation plateau-condition. Materials and Methods: Hundred male Kunming mice were randomly divided into five groups (n=20): one normoxia control group (NCG), one hypoxia control group (HCG), and three PNS groups in low dosage (0.42 g/kg), mid dosage (1.11 g/kg), and high dosage (11.53 g/kg). HCG and PNS groups were fed at a simulated elevation of 5 km. NCG and HCG were intragastric administrated with distilled water. After continuous administration for 10 days, the exhaustive swimming time, glycogen contents in liver, blood lactic acid (BLA), and blood glucose were determined. Results: Exposure of the mice to simulation plateau-condition with 5 km altitude for 10 days caused significant decrease of exercise tolerance compared to normoxia environment. The swimming time and glycogen contents in liver were significantly increased at all tested concentration (0.42, 1.11, and 11.53 g/kg). The area under the BLA curve was significantly decreased at the concentration of 0.42 g/ kg. The blood glucose of resting and 0 minutes after swimming were significantly increased by 29.31% and 15.51% (P<0.05) at a concentration of 11.53 g/kg compared to their own control groups, respectively. Conclusion: These results indicate that PNS could postpone the appearance of fatigue and accelerate the restoration of fatigue in plateau environment, especially in low dosage (0.42 g/kg) case.

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      Zhou, S., Wang, Y., Tian, H., Huang, Q., Gao, Y., & Zhang, G. (2012). Anti-fatigue effects of Panax notoginseng in simulation plateau-condition mice. Pharmacognosy Magazine, 8(31), 197–201. https://doi.org/10.4103/0973-1296.99284