The Effects of a Single Preanesthetic dose of Dexmedetomidine on Propofol Induction, Hemodynamics, and Cardiovascular Parameters
Padmini Vishwanath1, Rammoorthi Rao1, Sunil Baikadi Vasudevarao1★★ Corresponding author
- 1Department of Anaesthesia, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
CORRESPONDENCE
Sunil Baikadi Vasudevarao
Kasturba Medical College, Mangalore, Karnataka, India.
Received: 13-09-2019; Revised: 17-12-2019; Accepted: 06-05-2020.
Volume 11, Issue 1 · pp. 8–12 · PUBLISHED 12 September 2020 · DOI: 10.4103/jpp.JPP_91_19
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ABSTRACT
Objective: To find out the dose of propofol consumption for induction and also the variation in hemodynamics following single-dose dexmedetomidine premedication. Methods: A total of 60 American Society of Anesthesiologists Class 1 and 2 patients aged between 18 and 80 years, posted for elective surgeries were randomized into two groups: Group C – premedication with 2 mcg/kg fentanyl and Group D – premedication with 1 mcg/kg dexmedetomidine + 2 mcg/kg fentanyl. Both groups were preloaded with 10 ml/kg crystalloid solution. The parameters measured were propofol requirements, heart rate (HR), mean arterial pressure (MAP), cardiac index (CI), cardiac output (CO), and stroke volume variation (SVV). Results: Propofol requirements were 26.6% lesser in Group D (P < 0.001). In Group C, HR was significantly low at baseline (P = 0.008), induction (P = 0.006), and at intubation (P = 0.001) in Group D. Cardiovascular parameters such as MAP (P = 0.007), CI (P = 0.038), and CO (P = 0.021) were significantly lower in Group D compared to Group C only at baseline. There were no differences at any other point during the study. SVV was noted to be significantly lower (P = 0.018) in Group D only at intubation. Conclusion: Dexmedetomidine decreases the requirements of propofol for induction and also attenuates the hemodynamic response to intubation. Cardiovascular parameters such as MAP, CI, and CO were significantly lower in Group D only at baseline. Hemodynamic stability is mainly attributed to adequate preloading and less propofol requirement in the dexmedetomidine group.
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Vishwanath, P., Rao, R., & Vasudevarao, S. B. (2020). The Effects of a Single Preanesthetic dose of Dexmedetomidine on Propofol Induction, Hemodynamics, and Cardiovascular Parameters. Journal of Pharmacology and Pharmacotherapeutics, 11(1), 8–12. https://doi.org/10.4103/jpp.JPP_91_19