Role of Vitamin B Complex as an Add-on Therapy to Diclofenac in Patients with Primary Osteoarthritis of the Knee
Jasmine Kaur1, Seema Rani1, Anil Gulia2, Garima Bhutani1, Sanjeev Kumar2★, Arvind Narwat1★ Corresponding author
- 1Department of Pharmacology, BPS Government Medical College for Women, Khanpur, Kalan, Sonipat, Haryana, India.
- 2Department of Orthopedics, BPS Government Medical College for Women, Khanpur, Kalan, Sonipat, Haryana, India.
CORRESPONDENCE
Sanjeev Kumar
Department of Orthopedics, BPS Government Medical College for Women, Khanpur, Kalan, Sonipat, Haryana, India.
Received: 11-03-2021; Revised: 21-05-2021; Accepted: 18-06-2021.
Volume 12, Issue 2 · pp. 68–72 · PUBLISHED 17 September 2021 · DOI: 10.4103/jpp.jpp_32_21
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ABSTRACT
Objective: This study was conducted with the aim to evaluate the efficacy and safety of Vitamin B complex as an add‑on therapy to diclofenac in patients with primary osteoarthritis(OA) of the knee. Materials and Methods: In this prospective, open‑labeled, randomized, and comparative clinical study, a total of 130 patients of age >40 years with primary OA of knee attending orthopedics OPD were randomly allocated into two groups of 65 each, i.e., Group D and Group B. In Group D, patients received tablet diclofenac 75 mg and in Group B, patients received tablet Vitamin B complex along with diclofenac once daily for 4 weeks, respectively. Clinical assessment was done at baseline and at the end of 4 weeks and 8 weeks by the visual analog scale (VAS), WOMAC index, and Lequesne index. Results: During the intergroup comparison, it was found that Vitamin B complex as an add‑on therapy to diclofenac produced statistically significant reduction in mean VAS pain score (P < 0.05). However, the difference in mean WOMAC index and Lequesne index was not statistically different at 4 and 8 weeks between the two groups (P > 0.05). Mild side effects were seen at 4 weeks, but no side effects persisted up to 8 weeks in both the groups. Conclusion: The present study suggested that Vitamin B complex as an add‑on therapy was found to cause a significant reduction in pain score. It could be a promising drug in patients with OA to improve the analgesic effect, when combined can reduce the dose of diclofenac, thereby minimizing the side effects.
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Kaur, J., Rani, S., Gulia, A., Bhutani, G., Kumar, S., & Narwat, A. (2021). Role of Vitamin B Complex as an Add-on Therapy to Diclofenac in Patients with Primary Osteoarthritis of the Knee. Journal of Pharmacology and Pharmacotherapeutics, 12(2), 68–72. https://doi.org/10.4103/jpp.jpp_32_21