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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    The Association Between Serum Vitamin D Levels and Serum Cathelicidin Antimicrobial Peptide (CAMP) Levels Among Tuberculosis Patients in Comparison with Control Subjects

    Kiran Belur1★, Prema Arunachalam2, Jamuna Rani Raveendran1★ Corresponding author

    1. 1Department of Pharmacology, SRM MCH and RC, Potheri, Chengalpattu, Tamil Nadu, India.
    2. 2Department of Paediatrics, SRM MCH and RC, Potheri, Chengalpattu, Tamil Nadu, India.

    CORRESPONDENCE

    Kiran Belur

    Department of Pharmacology, SRM MCH and RC, Potheri, Chengalpattu, Tamil Nadu 603203, India.

    kiranv@srmist.edu.in

    Received: 09-11-2021; Revised: 17-02-2022; Accepted: 23-04-2022.

    Volume 13, Issue 2 · pp. 175–181 · PUBLISHED 2022 · DOI: 10.1177/0976500X221105760

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objectives: To compare the serum vitamin D and serum cathelicidin antimicrobial peptide (CAMP) levels among tuberculosis patients and healthy subjects and to determine the association between serum vitamin D and cathelicidin in tuberculosis. Materials and Methods: This is a case-control study carried out at the pulmonary medicine and pediatrics departments of a tertiary care hospital in Chengalpattu. The study included 180 tuberculosis cases and 90 control subjects of both sexes between the age group of 1 to 80 years. Serum was used to estimate vitamin D and CAMP. The study was analyzed using SPSS version 21 (IBM Corp. Armonk, New York). The results were evaluated using the chi-square test at a 95% confidence interval, and P value <.05 was considered highly significant. Results: This study observed vitamin D deficiency, vitamin D insufficiency, and optimum vitamin D among 55%, 41%, and 3.89% tuberculosis cases, respectively. Similarly, vitamin D deficiency, vitamin D insufficiency, and optimum vitamin D were seen in 40%, 50%, and 10% healthy controls, respectively. Conclusion: This study found no association between serum vitamin D and serum CAMP levels in tuberculosis patients and healthy controls.

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      Belur, K., Arunachalam, P., & Raveendran, J. R. (2022). The Association Between Serum Vitamin D Levels and Serum Cathelicidin Antimicrobial Peptide (CAMP) Levels Among Tuberculosis Patients in Comparison with Control Subjects. Journal of Pharmacology and Pharmacotherapeutics, 13(2), 175–181. https://doi.org/10.1177/0976500X221105760