Volume 13, Issue 2

2022 · pp. 113–206 · 12 articles

Volume: 13
Issue: 2
Published: 2022
Pages: 113–206
Articles: 12
Sections: 3
ISSN: ISSN: Print - 0976-500X, Online - 0976-5018
Journal: J Pharmacol. Pharmacother.

Review Article Research Article Case Report

In this issue

Review Article

Review
Medical Professionalism and Ethics
Mira K. Desai, Jigar Dilipkumar Kapadia
pp. 113–118 · DOI: 10.1177/0976500X221111448 · Published 2022
Frequent media reports of disputes between medical teachers, resident doctors, and patients have been disturbing thus indicating an increasing gap and decline in the values of the profession. The foundation of medical pr…
Review
Secukinumab: A Silver Lining in Dermatology
Dhanaraj Manoharan, Ravi Vignesh N., Srinivasan Shreya, Saravanan Suzsmi L.
pp. 119–124 · DOI: 10.1177/0976500X221105921 · Published 2022
Secukinumab, a fully human monoclonal antibody, is a biological agent that targets interleukin-17A. Secukinumab is used in the management of the common dermatological entity - plaque-type psoriasis and its various types,…
Review
The Role of TGF-β in Cognitive Decline Associated with Radiotherapy in Brain Tumor
G. S. Swarna Bindu, Dithu Thekkekkara, T. Lakshmi Narayanan, Jiju Narayanan, Sri Harsha Chalasani, S. N. Manjula
pp. 125–134 · DOI: 10.1177/0976500X221107503 · Published 2022
Cognitive decline is a late adverse event in brain tumor survivors. The patients receiving radiation treatment exhibit a wide range of damage and impairment in attention, memory, and executive function compared to the un…

Research Article

Article
In Silico Modeling and Docking Analysis of CTX-M-5, Cefotaxime-Hydrolyzing β-Lactamase from Human-Associated Salmonella Typhimurium
S. K. Md. Jasmine, Vidya Sagar Reddy G., Neelima Gorityala, Someswar Rao Sagurthi, Sandhya Mungapati, Kota Neela Manikanta, Uday Sankar Allam
pp. 135–147 · DOI: 10.1177/0976500X221109721 · Published 2022
Objective: To computationally model the CTX-M-5 β-lactamase and establish its structure, which is exclusively present in human-associated Salmonella. Methods: The CTX-M-5 aminoacid sequence (Uniprot ID:O65975) of Salmone…
Article
The Effects of Deoxyelephantopin on the Akt/mTOR/P70S6K Signaling Pathway in MCF-7 Breast Carcinoma Cells In Vitro
Wan Failiza Wan Mohamad Fazil, Azimah Amanah, Muhammad Asyraf Abduraman, Shaida Fariza Sulaiman, Habibah Abdul Wahab, Mei Lan Tan
pp. 148–159 · DOI: 10.1177/0976500X221114003 · Published 2022
Objective: To determine the effects of deoxyelephantopin on mTOR and its related target molecules (Akt/mTOR/P70S6K) in the ER-positive breast cancer cell line. Materials and Methods: Primary in silico simulations were de…
Article
Application of Physiologically Based Pharmacokinetic Modeling of Lamotrigine Using PK-Sim in Predicting the Impact of Drug Interactions and Dosage Adjustment
Mohammed Farhan, Prathvi Rani, Fatimazahra Moledina, Thomas George, Hari Prabhath Tummala, Surulivelrajan Mallayasamy
pp. 160–166 · DOI: 10.1177/0976500X221111455 · Published 2022
Objectives: To build a lamotrigine (LTG) physiologically based pharmacokinetic (PBPK) model (LTG PBPK) and compare it to the clinical data from South Asian Indian patients and use this model to understand the drug intera…
Article
Pharmacokinetics of a Novel Sustained-Release Vitamin C Oral Tablet: A Single Dose, Randomized, Double-Blind, Placebo-Controlled Trial
Rajat Shah, Shefali Thanawala, Ramapalaniappan Abiraamasundari
pp. 167–174 · DOI: 10.1177/0976500X221111669 · Published 2022
Objectives: To evaluate the pharmacokinetics of a novel sustained-release oral tablet (C-Fence, Inventia Healthcare Limited, Mumbai, India). Methods: We conducted a randomized, placebo-controlled, parallel-design, 500 mg…
Article
The Association Between Serum Vitamin D Levels and Serum Cathelicidin Antimicrobial Peptide (CAMP) Levels Among Tuberculosis Patients in Comparison with Control Subjects
Kiran Belur, Prema Arunachalam, Jamuna Rani Raveendran
pp. 175–181 · DOI: 10.1177/0976500X221105760 · Published 2022
Objectives: To compare the serum vitamin D and serum cathelicidin antimicrobial peptide (CAMP) levels among tuberculosis patients and healthy subjects and to determine the association between serum vitamin D and cathelic…
Article
Antiemetic Efficacy of Prophylactic Ondansetron Versus Ondansetron with Dexamethasone Combination Therapies in Women Undergoing Breast Surgeries: A Randomized Controlled Trial
Apoorva Devarahosahally Shivanna, Reena R. Kadni, Syed Farzan Tausif, Varghese K. Zachariah
pp. 182–189 · DOI: 10.1177/0976500X221105758 · Published 2022
Objective: To compare the prophylactic antiemetic efficacy of ondansetron monotherapy with that of the combination of ondansetron and dexamethasone in the prevention on postoperative nausea and vomiting (PONV) in breast …
Article
Curcumin-Impregnated Drug Delivery Systems May Show Promise in the Treatment of Diseases Secondary to Traumatic Brain Injury: Systematic Review
İbrahim Yilmaz, Numan Karaarslan, Hakan Somay, Hanefi Ozbek, Ozkan Ates
pp. 190–196 · DOI: 10.1177/0976500X221112479 · Published 2022
Objective: To find out whether curcumin can be effective in the treatment of traumatic brain injury (TBI). Methods: A comprehensive and systematic literature search in the PubMed electronic database was performed. Descri…
Article
Adverse Drug Reactions to Antifungals Used in the Management of COVID-19 Associated Rhino-Orbito-Cerebral Mucormycosis
Smrati Tiwari, Zahaan Vakil
pp. 197–202 · DOI: 10.1177/0976500X221105759 · Published 2022
Objectives: To determine the incidence and frequency of adverse drug reactions (ADRs) to find out factors, if any contributing to the same, while also exploring the use of amphotericin B deoxycholate as a cheaper and saf…

Case Report

Article
Low-Dose Tramadol-Induced Seizure: A Case Report
Himadri Sekhar Dasgupta, Debashis Priyadarshan Sahoo, Bhupen Barman, Dhriti Brahma
pp. 203–206 · DOI: 10.1177/0976500X221107494 · Published 2022
Tramadol is a weak mu (µ) opioid receptor agonist that acts by inhibiting serotonin and norepinephrine uptake. Tramadol undergoes extensive hepatic metabolism by a number of pathways, including CYP2D6 and CYP3A4, and by …