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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Curcumin-Impregnated Drug Delivery Systems May Show Promise in the Treatment of Diseases Secondary to Traumatic Brain Injury: Systematic Review

    İbrahim Yilmaz1,2★, Numan Karaarslan3, Hakan Somay4, Hanefi Ozbek5, Ozkan Ates6★ Corresponding author

    1. 1Ministry of Health, Dr Ismail Fehmi Cumalioglu City Hospital, Unit of Pharmacovigilance and Rational Use of Drugs, Tekirdag, Turkey.
    2. 2Department of Medical Services and Techniques, Vocational School of Health Services, Istanbul Rumeli University, Istanbul, Turkey.
    3. 3Department of Neurosurgery, Halic University School of Medicine, Istanbul, Turkey.
    4. 4Department of Neurosurgery, Kadikoy Medicana Hospital, Istanbul, Turkey.
    5. 5Department of Medical Pharmacology, İzmir Bakırçay University School of Medicine, Izmir, Turkey.
    6. 6Department of Neurosurgery, Istanbul Koc University School of Medicine, Istanbul, Turkey.

    CORRESPONDENCE

    İbrahim Yilmaz

    Ibrahim Yilmaz, Ministry of Health, Dr Ismail Fehmi Cumalioglu City Hospital, Unit of Pharmacovigilance and Rational Use of Drugs, Yemen Street, No:13, Tekirdag 59020, Turkey; Department of Medical Services and Techniques, Vocational School of Health Services, Istanbul Rumeli University, Istanbul, Istanbul 34570, Turkey.

    dryilmazi@yahoo.com

    Received: 02-05-2022; Revised: 16-06-2022; Accepted: 16-06-2022.

    Volume 13, Issue 2 · pp. 190–196 · PUBLISHED 2022 · DOI: 10.1177/0976500X221112479

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objective: To find out whether curcumin can be effective in the treatment of traumatic brain injury (TBI). Methods: A comprehensive and systematic literature search in the PubMed electronic database was performed. Descriptive statistics were used to evaluate the data obtained. The results were presented as frequency and percentage (%) or amount. Results: Two clinical trials investigated curcumin for the treatment of TBI. One study tested curcumin in living mammalian subjects using an amyloLipid nanovesicle. In three studies, curcumin was investigated together with the drug delivery system for the treatment of TBI. Conclusion: Drug delivery systems prepared with nanomaterials may have a potential therapeutic effect in treating TBI by increasing neuroprotection because they can penetrate the central nervous system more rapidly.

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      Yilmaz, B., Karaarslan, N., Somay, H., Ozbek, H., & Ates, O. (2022). Curcumin-Impregnated Drug Delivery Systems May Show Promise in the Treatment of Diseases Secondary to Traumatic Brain Injury: Systematic Review. Journal of Pharmacology and Pharmacotherapeutics, 13(2), 190–196. https://doi.org/10.1177/0976500X221112479