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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial

    Venkata Aksheena Varahi Vedam1★, Mohan Krishna Ghanta2, Suvarna Jyothi Kantipudi3, Darling Chellathai David4, Melanathuru Vijayalakshmi5, Poojith Nuthalapati6★ Corresponding author

    1. 1Department of Pharmacology, ESIC Medical College & PGIMSR, K.K. Nagar, Chennai, Tamil Nadu, India.
    2. 2Department of Pharmacology, MVJ Medical College and Research Hospital, Hoskote, Bangalore, Karnataka, India.
    3. 3Department of Psychiatry, Sri Ramachandra Medical College and Research Institute, SRIHER-DU, Chennai, Tamil Nadu, India.
    4. 4Department of Pharmacology, Sri Ramachandra Medical College and Research Institute, SRIHER-DU, Porur, Chennai, Tamil Nadu, India.
    5. 5Department of Biotechnology, Dr M.G.R Educational, and Research Institute Maduravoyal Chennai, Tamil Nadu, India.
    6. 6Sri Ramachandra Medical College and Research Institute, SRIHER-DU, Porur, Chennai, Tamil Nadu, India.

    CORRESPONDENCE

    Venkata Aksheena Varahi Vedam

    Department of Pharmacology, ESIC Medical College and PGIMSR, K.K. Nagar, Chennai, Tamil Nadu 600078, India.

    varahivedam1891@gmail.com

    Revised: 17-06-2022; Accepted: 08-08-2022.

    Volume 13, Issue 3 · pp. 284–292 · PUBLISHED 2022 · DOI: 10.1177/0976500X221128649

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objectives: To find out the relation between homocysteine levels in peripheral blood and the effectiveness as well as the safety of haloperidol and olanzapine in schizophrenia treatment. Materials and Methods: A prospective randomized parallel-group open-label interventional clinical trial was conducted on 40 mild to moderate schizophrenia patients. To compare the efficacy of olanzapine and haloperidol Brief Psychiatric Rating Scale (BPRS) score was used. Homocysteine levels of peripheral blood and Abnormal Involuntary Movement Scale scores were evaluated. Results: BPRS score improved in both groups on day 14 and day 28. But significantly more with olanzapine (P value =.001). The olanzapine group showed a higher reduction (13.91±0.47 to 9.74±0.5) in homocysteine levels than the haloperidol group. Also, the BPRS scores negatively correlated (r = –0.66) to homocysteine levels. Conclusion: Therefore, our study shows that peripheral blood homocysteine levels can be used to predict and assess the treatment outcome in schizophrenia patients. Biomarker driven approach in schizophrenia will allow the patients to be treated promptly with the right drug. In this light, personalized treatment holds great potential in the future.

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      Vedam, V. A. V., Ghanta, M. K., Kantipudi, S. J., David, D. C., Vijayalakshmi, M., & Nuthalapati, P. (2022). Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial. Journal of Pharmacology and Pharmacotherapeutics, 13(3), 284–292. https://doi.org/10.1177/0976500X221128649