Volume 13, Issue 3

2022 · pp. 215–299 · 11 articles

Volume: 13
Issue: 3
Published: 2022
Pages: 215–299
Articles: 11
Sections: 3
ISSN: ISSN: Print - 0976-500X, Online - 0976-5018
Journal: J Pharmacol. Pharmacother.

Review Article Research Article Short Review

In this issue

Review Article

Review
Treatment Considerations and Pharmacist Collaborative Care in Diabetic Ketoacidosis Management
Alanood Algarni
pp. 215–221 · DOI: 10.1177/0976500X221128643 · Published 2022
Diabetic ketoacidosis (DKA) is a medical emergency caused by the lack of insulin. Metabolic acidosis, hyperglycemia, and ketoacidosis are its defining features. Insulin deficiency can cause DKA either in the presence or …
Review
Tapinarof: A Felicitous Discovery in Psoriasis Treatment
Indumathi Prabath, Subhiksha Subramanian, Jamuna Rani
pp. 222–228 · DOI: 10.1177/0976500X221130851 · Published 2022
Tapinarof is a novel topical formulation approved recently, in May 2022, by the United States Food and Drug Administration to treat plaque psoriasis. Existing topical therapies for psoriasis are limited by systemic and l…
Review
Role of Nrf2 Pathway Activation in Neurological Disorder: A Brief Review
Mohammad Zubair Baba, S. Gomathy, Umair Wahedi
pp. 229–238 · DOI: 10.1177/0976500X221128855 · Published 2022
Oxidative stress plays a crucial role in the emergence of numerous neurodegenerative diseases, with protein accumulation and mitochondrial damage, which result in neurological disorders. To minimize oxidative stress, sev…
Review
A Comparative Study of Chromium: Therapeutic Uses and Toxicological Effects on Human Health
Anaiska Ray, Jayshri Sadashiv Jankar
pp. 239–245 · DOI: 10.1177/0976500X221128646 · Published 2022
Chromium is an essential trace element whose deficiency can cause impairment of glucose tolerance, growth and various biological functions. There are two isotopes of chromium-trivalent chromium and hexavalent chromium. B…
Review
A Review on the Pharmacological Importance of PDE5 and Its Inhibition to Manage Biomedical Conditions
Queen Saikia, Ajit Hazarika, Ritu Mishra
pp. 246–257 · DOI: 10.1177/0976500X221129008 · Published 2022
Phosphodiesterase type 5 (PDE5) is a cyclic GMP (cGMP) specific protein. It hydrolyzes the phosphodiesterase linkage and catalyzes the conversion of cGMP to 5' GMP, which controls different physiological activities of th…
Review
Transgenic Rodent Models in Toxicological and Environmental Research: Future Perspectives
Parayil Varghese Christapher, Thanapakiam Ganeson, Suresh V. Chinni, Subramani Parasuraman
pp. 258–265 · DOI: 10.1177/0976500X221135691 · Published 2022
The coexistence of humans and animals has existed for centuries. Over the past decade, animal research has played a critical role in drug development and discovery. More and more diverse animals, including transgenic ani…

Research Article

Article
Exposure to Azathioprine Metabolites and Clinical Outcome in Indian Patients with Crohn’s Disease
Ratna Prabha, Sumith K. Mathew, A. J. Joseph, Binu Susan Mathew
pp. 266–271 · DOI: 10.1177/0976500X221085804 · Published 2022
Aim: To determine the concentration of 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP), the interpatient variability, and the relationship with disease activity in patients with Chron’s disease on lon…
Article
A Prospective, Observational Study of the Spontaneous Reporting Patterns of Adverse Drug Reactions in a Tertiary Care Teaching Hospital
Santhosh Kumar Raju, Geetha S., Shobha Kamble
pp. 272–277 · DOI: 10.1177/0976500X221130841 · Published 2022
Objectives: To analyse the adverse drug reactions (ADRs) reported from clinical departments of a tertiary care hospital. Materials and Methods: A prospective, observational study to analyse the reported ADRs to the pharm…
Article
The Effect of Intravenous Ketamine After Spinal Anesthesia on the Duration of Postoperative Analgesia and Analgesic Requirement
Aparna Bagle, Spoorti Pujari, Krusha Shah, Shreyank Solanki, Chandrakala Singh
pp. 278–283 · DOI: 10.1177/0976500X221108533 · Published 2022
Objective: To evaluate the impact of ketamine following spinal anesthesia on the duration of postoperative analgesia and the need for analgesics. Methods: This was a prospective, randomized, double-blinded placebo-contro…
Article
Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial
Venkata Aksheena Varahi Vedam, Mohan Krishna Ghanta, Suvarna Jyothi Kantipudi, Darling Chellathai David, Melanathuru Vijayalakshmi, Poojith Nuthalapati
pp. 284–292 · DOI: 10.1177/0976500X221128649 · Published 2022
Objectives: To find out the relation between homocysteine levels in peripheral blood and the effectiveness as well as the safety of haloperidol and olanzapine in schizophrenia treatment. Materials and Methods: A prospect…

Short Review

Article
Progress Update on the Epidemiology of COVID-19 Variants and the Assessment Status of Developed Vaccines
Katharigatta N. Venugopala
pp. 293–299 · DOI: 10.1177/0976500X221138393 · Published 2022
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread rapidly and diffused to more than 180 countries at varying severities. This pandemic has accounted for increased mortality and morbidity in develope…