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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Review

    Various Factors Influencing the Enantiomers of Warfarin Pharmacokinetics: A Systematic Review of Population Pharmacokinetics

    Sirajudeen Mahaboob1,3, G.N.K. Ganesh1★, K.P. Arun2, S.D. Rajendran3★ Corresponding author

    1. 1Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, Tamil Nadu, India.
    2. 2Department of Pharmacy Practice, JSS College of Pharmacy, Ootacamund, Tamil Nadu, India.
    3. 3Scitus Pharma Services Pvt. Ltd., Kattupakkam, Chennai, Tamil Nadu, India.

    CORRESPONDENCE

    G.N.K. Ganesh

    Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, Tamil Nadu 643001, India.

    gnk@jssuni.edu.in

    Received: 25-07-2023; Revised: 28-09-2023; Accepted: 29-09-2023.

    Volume 14, Issue 3 · pp. 178–186 · PUBLISHED 2023 · DOI: 10.1177/0976500X231211401

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Warfarin is the most commonly prescribed anti-coagulant medication. Warfarin’s pharmacokinetics (PK) in its enantiomeric form have been reported to be highly variable. Five population pharmacokinetic model studies for warfarin were identified in this systematic review. This review summarized these studies and reported on various factors affecting warfarin PK. Most studies reported a one-compartment model with first-order absorption and elimination for both S-warfarin and R-warfarin. Warfarin disposition has been reported to be influenced by various factors, including gender, age, genetic variation, body surface area (BSA), concurrent drug, weight, and ethnicity. So, all of these factors must be considered when addressing this pharmacokinetic variability. These models should undergo an external evaluation to confirm their generalizability and to support model-informed dosing in clinical settings.

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        Mahaboob, S., Ganesh, G., Arun, K., & Rajendran, S. (2023). Various Factors Influencing the Enantiomers of Warfarin Pharmacokinetics: A Systematic Review of Population Pharmacokinetics. Journal of Pharmacology and Pharmacotherapeutics, 14(3), 178–186. https://doi.org/10.1177/0976500X231211401