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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Review

    A Review on the Poisonous Plant Cleistanthus collinus

    Raman P. Priyadharsini1, Subramani Parasuraman2,3★, Sagar Puli4, Ramasamy Raveendran5★ Corresponding author

    1. 1Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Karaikal, Puducherry, INDIA.
    2. 2Unit of Pharmacology, Toxicology and Basic Health Sciences, Faculty of Pharmacy, AIMST University, Bedong, Kedah Darul Aman, MALAYSIA.
    3. 3Centre for Global Health Research, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, INDIA.
    4. 4Department of Pharmacology, Dr. Chandramma Dayananda Sagar Institute of Medical Education & Research, Deverakaggalahalli, Ramanagara, Karnataka, INDIA.
    5. 5Department of Pharmacology, JIPMER, Puducherry, INDIA.

    CORRESPONDENCE

    Subramani Parasuraman

    Unit of Pharmacology, Toxicology and Basic Health Sciences, Faculty of Pharmacy, AIMST University, Bedong, Kedah Darul Aman, MALAYSIA.

    parasuraman@aimst.edu.my

    Received: 02-04-2024; Revised: 18-04-2024; Accepted: 09-05-2024.

    Volume 15, Issue 3 · pp. 213–220 · PUBLISHED 2024 · DOI: 10.1177/0976500X241257741

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Cleistanthus collinus is a toxic plant belonging to the Euphorbiaceae family, and all parts of the plant are poisonous. It is used as suicidal, homicidal, cattle and fish poison and for inducing criminal abortion. The leaves and plant parts are consumed in various forms for homicidal and suicidal and it results in symptoms such as chest pain, dyspnea, central nervous system symptoms, and vision disturbances. There is no specific antidote for the C. collinus poisoning. The percentage of mortality with C. collinus poisoning varies from 20% to 50%, and the mortality depends on the amount and mode of consumption of the leaves. The major phytoconstituents of the plant include ellagic acid, diphyllin, collinusin, cleistanthin A, and cleistanthin B. The two major compounds cleistanthin A and cleistanthin B were evaluated for pharmacological activities such as antineoplastic activity, antiviral activity, diuretic activity, neuromuscular blocking property, alpha receptor blocking property, and antioxidant effect. The current review focuses on the toxicological and pharmacological properties of this plant and its phytoconstituents.

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      Priyadharsini, R. P., Parasuraman, S., Puli, S., & Raveendran, R. (2024). A Review on the Poisonous Plant Cleistanthus collinus. Journal of Pharmacology and Pharmacotherapeutics, 15(3), 213–220. https://doi.org/10.1177/0976500X241257741