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    Review

    Review on Exploring Role of Vitamin D on Alzheimer’s Disease: Mechanistic Insights and Implications

    Nagaraju Bandaru1★, Mohan Gandhi Bonthu1, Alluri Pavani Gayatri2, Shashikala Metri3, Perli Kranti Kumar1, Aneesha Addanki4, Srilaksmi Nallapaty5, Karri Swathi Priya6, Dodda Tulase Nadhreddy1, P. N. S. Gowravi7★ Corresponding author

    1. 1Department of Pharmacology and Pharmaceutical Quality Assurance, School of Pharmaceutical Sciences (SOPS), Sandip University, Nashik, Maharashtra, INDIA.
    2. 2Department of Pharmacology, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra, INDIA.
    3. 3Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Hyderabad, Telangana, INDIA.
    4. 4Department of Pharmaceutical Analysis, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, INDIA.
    5. 5Department of Pharmaceutical Chemistry, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Andhra Pradesh, INDIA.
    6. 6Department of Pharmacognosy, Srinivasarao College of Pharmacy, P.M. Palem, Visakhapatnam, Andhra Pradesh, INDIA.
    7. 7Department of Pharmacy Practice, Andhra University College of Pharmaceutical Sciences, Andhra University South Campus, Chinna Waltair, Andhra Pradesh, INDIA.

    CORRESPONDENCE

    Nagaraju Bandaru

    Department of Pharmacology and Pharmaceutical Quality Assurance, School of Pharmaceutical Sciences (SOPS), Sandip University, Nashik, Maharashtra, INDIA.

    bnrajupharma@gmail.com

    Received: 07-10-2024; Revised: 28-11-2024; Accepted: 09-12-2024.

    Volume 16, Issue 2 · pp. 164–171 · PUBLISHED 2025 · DOI: 10.1177/0976500X241312726

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Background: Alzheimer’s disease (AD) is a complex neurological disorder characterized by neuronal loss and progressive cognitive decline. The disease progression is influenced by both environmental and genetic factors. Recent research highlights the significant role of vitamin D in the pathological progression of AD. Objectives: This review aims to comprehensively analyze the interplay between vitamin D and Alzheimer’s disease, focusing on its molecular mechanisms, epidemiological evidence, and therapeutic implications. Methodology: An extensive literature review was conducted to explore the molecular pathways by which vitamin D affects key pathological processes in AD, including amyloid-beta deposition, oxidative stress, neuronal inflammation, and tau phosphorylation. Epidemiological studies linking vitamin D status with AD prevalence and clinical outcomes were also analyzed, along with data from research trials investigating the efficacy of vitamin D supplementation in AD prevention and management. Results: Vitamin D deficiency is associated with increased cognitive decline and heightened risk of developing AD. The review highlights the therapeutic potential of vitamin D supplementation in mitigating AD progression through its effects on pathological processes. However, challenges and controversies remain regarding the efficacy, optimal dosing regimens, and therapeutic strategies of vitamin D intake. Conclusion: This review underscores the role of vitamin D as a modifiable factor and therapeutic target in Alzheimer’s disease. Further research is required to establish definitive dosing regimens and strategies to optimize the use of vitamin D in preventing and managing this debilitating neurological disorder.

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      Bandaru, N., Bonthu, M. G., Gayatri, A. P., Metri, S., Kumar, P. K., Addanki, A., Nallapaty, S., Priya, K. S., Nadhreddy, D. T., & Gowravi, P. N. S. (2025). Review on Exploring Role of Vitamin D on Alzheimer’s Disease: Mechanistic Insights and Implications. Journal of Pharmacology and Pharmacotherapeutics, 16(2), 164–171. https://doi.org/10.1177/0976500X241312726