Volume 16, Issue 2

Cephalosporins Use in Pediatric Healthcare: A Comprehensive Review and Policy Considerations in Kingdom of Saudi Arabia

Mohammed K. Alshammari, Hind M. Al Osaimi, Norah F. Alshehri, Raneem F. Masoud, Alaa O. Abdulaal, Bashair Z. Al Qaidi

pp. 129–142 · DOI: 10.1177/0976500X241303306 · Published 2025

Background: Pediatric wellbeing and health outcomes are among the leading indicators of World Health Organization (WHO). Growing infections and risk of antibiotic resistance have appeared to be one of the main cause if m…

An In-depth Review of the Off-label Use of Apremilast in Dermatology

Aditya Kumar Bubna, Vinayak Viplav

pp. 143–163 · DOI: 10.1177/0976500X241303186 · Published 2025

Background: Apremilast is a phosphodiesterase-4 (PDE-4) inhibitor approved by the US-Food and Drug Administration (US-FDA) for the management of adult patients with plaque psoriasis (who are candidates for phototherapy/s…

Review on Exploring Role of Vitamin D on Alzheimer’s Disease: Mechanistic Insights and Implications

Nagaraju Bandaru, Mohan Gandhi Bonthu, Alluri Pavani Gayatri, Shashikala Metri, Perli Kranti Kumar, Aneesha Addanki, Srilaksmi Nallapaty, Karri Swathi Priya, Dodda Tulase Nadhreddy, P. N. S. Gowravi

pp. 164–171 · DOI: 10.1177/0976500X241312726 · Published 2025

Background: Alzheimer’s disease (AD) is a complex neurological disorder characterized by neuronal loss and progressive cognitive decline. The disease progression is influenced by both environmental and genetic factors. R…

Multiomics and Molecular Docking Approaches to Elucidate Desmostachya bipinnata-Derived Multitargeting Agents for Oral Squamous Cell Carcinoma

Nitya Krishnasamy, Ramya Ramadoss, Kochli Channapa Niranjan, Vikram S Amberkar, Haris Chandra Sahoo, Poorna Devadoss

pp. 172–184 · DOI: 10.1177/0976500X241299231 · Published 2025

Background: Oral squamous cell carcinoma (OSCC) is a prevalent form of head and neck cancer characterized by aggres-sive behavior and a poor prognosis. Conventional therapies have demonstrated limited effectiveness, unde…

Immunomodulatory Effects of Andrographis paniculata Leaf Extract in Cyclophosphamide-induced Immunosuppressed Mice

Patrick A. Kalona, Uma Sundaresan, Chellappandian Muthiah, Ariharasivakumar Ganesan

pp. 185–192 · DOI: 10.1177/0976500X241299159 · Published 2025

Background: Cyclophosphamide is one of the most extensively used chemotherapeutic drugs and is employed to treat several malignancies. Cyclophosphamide often comes with several unpleasant side effects. The primary negati…

A Comprehensive Analysis of Use of Small Laboratory Animals in Preclinical Research: A Five-Year Quantitative Descriptive Analysis

Ajay Gattani, Komal Khurade, Raakhi Tripathi, Rajmohan Seetharaman, Sharmila Jalgaonkar

pp. 193–201 · DOI: 10.1177/0976500X241299162 · Published 2025

Background: Animal models play a critical role in biomedical research, yet comprehensive data on the types and distribution of animals used in different research contexts are sparse. Objectives: This study aims to provid…

FEA-based Virtual Operation and Stress Distribution Analysis of DHS Screws in Proximal Femoral Bone Fractures: A Strategic Guide for Orthopedic Surgeons in Operational Planning

Aashish Joshi, Kailash Karande, Ravindra Gunaki

pp. 202–213 · DOI: 10.1177/0976500X241303572 · Published 2025

Background: Accidents are the major reasons causing hip bone fractures. These are due to reduced bone density due to aging effect which may cause fractures typically in proximal part of the femur bone. Objectives: The pu…

Clinical Characteristics and Risk Factors for Persistent Thrombocytopenia among Pediatric Patients after Bone Marrow Transplant in Saudi Arabia: A 3-Year Retrospective Observational Analysis from Tertiary Hospital

Mohammed Kanan, Abdullah Almotairi, Faisal Alrumaih, Reem Hammad, Mohammed Almotairi

pp. 214–225 · DOI: 10.1177/0976500X241303618 · Published 2025

Background: Bone marrow transplantation (BMT) is a crucial treatment for pediatric patients with various hematological, oncological, and genetic diseases. However, persistent thrombocytopenia (PT) post-transplantation po…

An Observational Study on Prescription Patterns of Drugs and Psychiatric Disorders Occurring in Child and Adolescent Patients in a Tertiary Care Hospital

Akella Krishna Sowmya, Sunil Kumar Pandey

pp. 226–233 · DOI: 10.1177/0976500X241305442 · Published 2025

Background: Mental health issues in children and adolescents are quite significant. Despite their impact, research on psychiatric disorders in these age groups is limited. This study aims to evaluate the prescription pat…

Comparison and Estimation of Salivary sTREM-1 and IL-1β in Periodontitis and Diabetes Mellitus Patients before and after Non-surgical Periodontal Therapy using Hyaluronic Acid and Diode LASER: A Clinical Trial

Visha MG, Deepak Moses Ravindran, Balaji SK, Lekha Ashokkumar

pp. 234–242 · DOI: 10.1177/0976500X241306178 · Published 2025

Background: Periodontal disease is a chronic inflammatory disease that activates the innate immune response. Activation of the TREM-1 signaling pathway promotes the synthesis of inflammatory cytokines like interleukin-1 …

WITHDRAWAL – Administrative Duplicate Publication: ML-powered Internet of Medical Things Structure for Heart Disease Prediction

pp. 243–243 · DOI: 10.1177/0976500X251319617 · Published 2025