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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastrus paniculatus seed oil: Neurobehavioural, biochemical, histological study

    Mrinmoy Chakrabarty1, Priyanka Bhat1, Sweta Kumari1, Avin D’Souza1, K. L. Bairy1★, Abhishek Chaturvedi2, Archana Natarajan2, Mohandas Rao K. G.3, Shobha Kamath2★ Corresponding author

    1. 1Departments of Pharmacology, College.
    2. 2Biochemistry, Kasturba Medical College.
    3. 3Anatomy, Melaka Manipal Medical College, Manipal University, Manipal, Karnataka, India Research Paper.

    CORRESPONDENCE

    K. L. Bairy

    Departments of Pharmacology, College.

    klbpharmacology@gmail.com

    Volume 3, Issue 2 · pp. 161–171 · PUBLISHED 2012 · DOI: 10.4103/0976-500X.95520

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objective: To investigate the effects of Celastrus paniculatus seed oil in preventing the onset of chronic aluminum induced cortico-hippocampal neurodegeneration and oxidative stress. Materials and Methods: An animal model of senile dementia of Alzheimer’s type was produced by administering aluminum as aluminum chloride (4.2 mg/kg) intraperitoneally to male Wistar rats for 60 days and results compared to untreated control. Neurobehavioral investigations of Morris water maze tests, passive avoidance test, rotarod test and biochemical estimations of acetylcholineterase, malondialdehyde, glucose-6-phosphate dehydrogenase, superoxide dismutase, and hemoglobin in blood were performed fortnightly which gauged the extent of global oxidative stress and progressive neural damage. Findings were fortified by the above enzyme assays and histology of brain at necropsy. Prophylactic oral C. paniculatus in two doses 0.5 ml and 1 ml, were given to animals and the results were analyzed in comparison to a similar rodent model with standard drug donepezil (0.5 mg/kg) intraperitoneally. Results: C. paniculatus showed a significant prevention in onset of aluminum induced neural insult and overall systemic oxidative stress which was corroborated by the enlisted neurobehavioral, biochemical, and histological evidence. Conclusion: C. paniculatus is a putative decelerator of Al-mediated Alzheimer’s like pathobiology.

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      Chakrabarty, M., Bhat, P., Kumari, S., D’Souza, A., Bairy, K. L., Chaturvedi, A., Natarajan, A., G., M. R. K., & Kamath, S. (2012). Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastrus paniculatus seed oil: Neurobehavioural, biochemical, histological study. Journal of Pharmacology and Pharmacotherapeutics, 3(2), 161–171. https://doi.org/10.4103/0976-500X.95520