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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Toxic epidermal necrolysis due to lamotrigine in a pediatric patient

    Manish J. Barvaliya1★, Mahendra K. Patel1, Tejas K. Patel2, C. B. Tripathi1★ Corresponding author

    1. 1Department of Pharmacology, Government Medical College, Bhavnagar.
    2. 2Department of Pharmacology, GMERS Medical College, Gotri, Vadodara, Gujarat, India Case Report.

    CORRESPONDENCE

    Manish J. Barvaliya

    Department of Pharmacology, Government Medical College, Bhavnagar.

    Volume 3, Issue 4 · pp. 336–338 · PUBLISHED 2012 · DOI: 10.4103/0976-500X.103695

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    A 12-year-male child developed toxic epidermal necrolysis (TEN) probably due to lamotrigine. The patient was on antiepileptic therapy (sodium valproate and clonazepam) since 6–7 months, and lamotrigine was added in the regimen 1–2 months back. A serious cutaneous reaction is more likely to occur during the first 2 months of starting lamotrigine. The use of lamotrigine as an add-on to valproate may have precipitated the reaction. Other drugs were ruled out based on the incubation period of TEN. Drug interactions should be kept in mind with multiple antiepileptic therapies. The patient died because of the severity of reactions and delay in starting the treatment with steroids. One must be vigilant in early detection of the reaction.

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      Barvaliya, M. J., Patel, M. K., Patel, T. K., & Tripathi, C. B. (2012). Toxic epidermal necrolysis due to lamotrigine in a pediatric patient. Journal of Pharmacology and Pharmacotherapeutics, 3(4), 336–338. https://doi.org/10.4103/0976-500X.103695