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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis‑infected pediatric patients: A single blind, randomized controlled trial

    Agnes L. Castillo1★, Marina O. Osi2, John Donnie A. Ramos2,3, Jean L. De Francia4, Marylaine U. Dujunco5, Peter F. Quilala6★ Corresponding author

    1. 1Faculty of Pharmacy.
    2. 2The Graduate School.
    3. 3College of Science, University of Santo Tomas.
    4. 4Institute of Pediatrics and Child Health.
    5. 5Departments of Internal Medicine, School.
    6. 6Emergency Medicine, St. Luke’s Medical Center, Manila, Philippines Research Paper.

    CORRESPONDENCE

    Agnes L. Castillo

    Faculty of Pharmacy.

    Volume 4, Issue 1 · pp. 39–46 · PUBLISHED 2013 · DOI: 10.4103/0976-500X.107668

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objective: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion . Materials and Methods: A single blind, randomized, controlled, pilot clinical study was performed in three government institutions to investigate clinical efficacy of T.cordifolia lotion in sixty‑six clinically‑diagnosed scabies‑infected patients. The patients were treated with T.cordifolia or permethrin lotions for three consecutive days for two weeks and clinical assessment of each patient was performed for five weeks. Results: T. cordifolia lotion and permethrin significantly reduced the mean global evaluation score after four weeks of treatment. The two lotions showed comparable effects as anti‑scabies agent. Moreover, the clearance time (days) and cure rate using the two lotions did not differ. Clinical improvement, mean clearance time and cure rate of T.cordifolia lotion are comparable with permethrin. Conclusions: Tinospora cordifolia lotion exhibits anti‑scabies activity comparable with permethrin. Its incorporation as therapeutic reagent in Sarcoptes scabiei infections is highly recommended.

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      Castillo, A. L., Osi, M. O., Ramos, J. D. A., Francia, J. L. D., Dujunco, M. U., & Quilala, P. F. (2013). Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis‑infected pediatric patients: A single blind, randomized controlled trial. Journal of Pharmacology and Pharmacotherapeutics, 4(1), 39–46. https://doi.org/10.4103/0976-500X.107668