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    Phcog.Net JOURNAL OF PHARMACOLOGY AND PHARMACOTHERAPEUTICS Volume 4 · Issue 1 2013 · pp. 1–80
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    Cover: Journal of Pharmacology and Pharmacotherapeutics

    Journal of Pharmacology and Pharmacotherapeutics

    Volume 4, Issue 1

    2013 · pp. 1–80 · 20 articles

    Volume
    4
    Issue
    1
    Published
    2013
    Pages
    1–80
    Articles
    20
    Sections
    10
    ISSN
    ISSN: Print - 0976-500X, Online - 0976-5018
    Journal
    J Pharmacol. Pharmacother.
    News and ViewsEditorialReview ArticleResearch PaperMini ReviewResearch LetterLetter to the EditorCase ReportWebwiseMolecules of the Millennium

    In this issue

    News and Views

    1. Article

      Continuing β-blockers after noncardiac surgery improves patient outcomes and lowers mortality

      G G

      pp. 74–75 · DOI: 10.4103/0976-500X.107694 · Published 2013

      In a study to determine the effect of β‑blocker continuation on outcomes in patients undergoing elective noncardiac surgery, it was found that (after adjusting for risk characteristics), failure to continue β‑blocker tre…

    2. Article

      Severe morning sickness patients get relief from anti-seizure drug

      Sivagnanam G

      pp. 75–75 · DOI: · Published 2013

      In a pilot study involving seven pregnant subjects with hyperemesis gravidarum, it has been found that therapy with gabapentin was associated with mean reductions in nausea and emesis from baseline to days 12-14 of 80% a…

    Editorial

    1. Forum Article

      When angels fall…are we lowering the standards of medical education in India?

      Gitanjali Batmanabane

      pp. 1–3 · DOI: 10.4103/0976-500X.107627 · Published 2013

      Medical teachers have been vested in the authority and the enormous responsibility of producing competent doctors. In a sense, they are the angels, who safe‑guard the health and well‑being of millions of our population. …

    Review Article

    1. Review

      Accessibility and use of essential medicines in health care: Current progress and challenges in India

      Dipika Bansal, Vilok K. Purohit

      pp. 13–18 · DOI: 10.4103/0976-500X.107642 · Published 2013

      Essential Medicine Concept, a major breakthrough in health care, started in 1977 when World Health Organization (WHO) published its first list. Appropriate use of essential medicines is one of the most cost‑effective com…

    Research Paper

    1. Article

      Effect of Casilan® on 13C-caffeine metabolism in overnight-fasted healthy Nigerian children

      Kazeem A. Oshikoya, Ken Smith

      pp. 19–26 · DOI: 10.4103/0976-500X.107648 · Published 2013

      Objective: To determine the effect of Casilan® on 13C-caffeine metabolism in healthy Nigerian children. Materials and Methods: Twelve healthy Nigerian children (male: six, female: six) aged 3–8 years were studied on thre…

    2. Article

      Effect of addition of either sitagliptin or pioglitazone in patients with uncontrolled type 2 diabetes mellitus on metformin: A randomized controlled trial

      Shalini Chawla, Nitin Kaushik, Narinder Pal Singh, Raktim Kumar Ghosh, Alpana Saxena

      pp. 27–32 · DOI: 10.4103/0976-500X.107656 · Published 2013

      Objective: To compare and study the dipeptidy1 peptidase‑4 (DPP‑4) inhibitors in combination with metformin against established combination therapies. Materials and Methods: This 16‑week study was designed to compare sit…

    3. Article

      Comparison of the efficacy and tolerability of ivabradine and ranolazine in patients of chronic stable angina pectoris

      Aditi Chaturvedi, Yogendra Singh, Harish Chaturvedi, Vijay Thawani, Sakshi Singla, Deepak Parihar

      pp. 33–33 · DOI: 10.4103/0976-500X.107663 · Published 2013

      Introduction: To compare the efficacy and tolerability of Ivabradine (IVA) and Ranolazine (RAN) in chronic angina patients. Materials and Methods: This was a follow‑on, open‑label trial conducted in a tertiary care hospi…

    4. Article

      Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis‑infected pediatric patients: A single blind, randomized controlled trial

      Agnes L. Castillo, Marina O. Osi, John Donnie A. Ramos, Jean L. De Francia, Marylaine U. Dujunco, Peter F. Quilala

      pp. 39–46 · DOI: 10.4103/0976-500X.107668 · Published 2013

      Objective: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion . Materials and Methods: A single blind, randomized, contr…

    5. Article

      Oleanolic acid prevents progression of streptozotocin induced diabetic nephropathy and protects renal microstructures in Sprague Dawley rats

      Vishal K. Dubey, Chandragouda R. Patil, Sarika M. Kamble, Priti S. Tidke, Kalpesh R. Patil, Pragnesh J. Maniya, Ramchandra B. Jadhav, Sudha P. Patil

      pp. 47–52 · DOI: 10.4103/0976-500X.107678 · Published 2013

      Objective: To study the effect of oleanolic acid (OA) on streptozotocin induced diabetic nephropathy in Sprague Dawley rats. Materials and Methods: Four weeks after intra‑peritoneal injection of streptozotocin (STZ; 55 m…

    6. Article

      Genetic variation and haplotype structure of the gene Vitamin K epoxide reductase complex, subunit 1 in the Tamilian population

      Dhakchinamoorthi Krishna Kumar, Deepak Gopal Shewade, Adithan Surendiran

      pp. 53–58 · DOI: 10.4103/0976-500X.107683 · Published 2013

      Objective: To study the genetic variation and haplotype structure of Vitamin K epoxide reductase complex, subunit 1 (VKORC1) gene in the Tamilian population. Materials And Methods: The study was performed on 210 unrelate…

    Mini Review

    1. Article

      The dawn of hedgehog inhibitors: Vismodegib

      Selvarajan Sandhiya, George Melvin, Srinivasamurthy Suresh Kumar, Steven Aibor Dkhar

      pp. 4–7 · DOI: 10.4103/0976-500X.107628 · Published 2013

      Cancer, one of the leading causes of death worldwide is estimated to increase to approximately 13.1 million by 2030. This has amplified the research in oncology towards the exploration of novel targets. Recently there ha…

    2. Article

      Strategies and challenges for safe injection practice in developing countries

      Sudesh Gyawali, Devendra Singh Rathore, P Ravi Shankar, Vikash Kumar KC

      pp. 8–12 · DOI: 10.4103/0976-500X.107634 · Published 2013

      Injection is one of the important health care procedures used globally to administer drugs. Its unsafe use can transmit various blood borne pathogens. This article aims to review the history and status of injection pract…

    Research Letter

    1. Article

      Prescribing pattern of gastroprotective agents with non-steroidal anti-inflammatory drugs

      V. S. Manohar, M Vinay, T. Jayasree, P. V. Kishan, S. Ubedulla, Rohit Dixit

      pp. 59–60 · DOI: 10.4103/0976-500X.107684 · Published 2013

      Non‑steroidal anti‑inflammatory drugs (NSAIDs) are most commonly used drugs for management of pain and inflammation. They represent a most widely prescribed class of medications and are used as over the counter drugs. NS…

    2. Article

      A study of non-prescription usage of antibiotics in the upper respiratory tract infections in the urban population

      Sangeeta Bhanwra

      pp. 62–64 · DOI: 10.4103/0976-500X.107687 · Published 2013

      In recent years the use and the overuse of antibiotics to treat Upper Respiratory Tract Infections (URTIs) has resulted in the development of resistance patterns across widespread areas. Most URTIs are self‑limiting vira…

    3. Article

      Calcium channel blocking activity of a dihydropyrimidine derivative (BKVIII) on rabbit’s aortic strip

      Rakesh Kumar, Balbir Kaur, V. K. Bajaj

      pp. 64–66 · DOI: 10.4103/0976-500X.107688 · Published 2013

      Test compound, 5‑Acyl‑6‑methyl‑4 (2′,3′‑methylenedioxy) phenyl‑2‑S‑ethyl‑1,4‑dihydropyrimidine have a calcium channel blocking activity and showed relaxant effect on aortic smooth muscle in higher doses as compared with …

    Letter to the Editor

    1. Article

      A structured course in laboratory animal science for postgraduates: Is it a necessity?

      Syed I. Shehnaz, Anoop K. Agarwal

      pp. 67–68 · DOI: 10.4103/0976-500X.107689 · Published 2013

      The utilization of AE in biomedical research demands a certain level of knowledge and manual dexterity in the scientists conducting the research. There is a wide diversity in the postgraduate curricula with respect to an…

    Case Report

    1. Article

      Aceclofenac induced Stevens‑Johnson/toxic epidermal necrolysis overlap syndrome

      Kaderthambi Hajamohideen Nooru Ameen, Rakesh Pinninti, Swathi Jami

      pp. 69–71 · DOI: 10.4103/0976-500X.107691 · Published 2013

      The purpose of this paper is to report a rare occurrence of Stevens‑Johnson/Toxic epidermal necrolysis (SJS/TEN) overlap syndrome after the use of aceclofenac. A 38 year old healthy adult male presented with rapidly evol…

    2. Article

      An unusual cause of cardiac arrest in a hospitalized patient

      Ranjan Shetty K., Anil Tumkur, Krishnamurthy Bhat, Biby Chacko

      pp. 72–73 · DOI: 10.4103/0976-500X.107692 · Published 2013

      We present an unusual case of 24 year old male who was hospitalized for dental procedure and developed cardiac arrest 2 days after the procedure. The patient presented with swelling of buccal cavity for which a biopsy wa…

    Webwise

    1. Article

      Critical appraisal skills programme

      Jatinder Singh

      pp. 76–7 · DOI: 10.4103/0976-500X.107697 · Published 2013

      A methodological approach coupled with the right tools and skills to match these methods is essential for finding meaningful results. The internet has redefined and simplified search capabilities of individuals by ensuri…

    Molecules of the Millennium

    1. Article

      Ticagrelor: An emerging oral antiplatelet agent

      Shivani Juneja, Kanchan Gupta, Sandeep Kaushal

      pp. 78–80 · DOI: 10.4103/0976-500X.107698 · Published 2013

      Acute coronary syndrome (ACS) is a leading cause of myocardial infarction in the world. It is one of the major cause of mortality in the present lifestyle scenario and a main reason for hospital admissions. A critical ro…