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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Calcium channel blocking activity of a dihydropyrimidine derivative (BKVIII) on rabbit’s aortic strip

    Rakesh Kumar1★, Balbir Kaur1, V. K. Bajaj1★ Corresponding author

    1. 1Department of Pharmacology, Government Medical College and Hospital, Chandigarh, India.

    CORRESPONDENCE

    Rakesh Kumar

    Department of Pharmacology, Government Medical College and Hospital, Chandigarh, India.

    bagharakesh@hotmail.com

    Volume 4, Issue 1 · pp. 64–66 · PUBLISHED 2013 · DOI: 10.4103/0976-500X.107688

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Test compound, 5‑Acyl‑6‑methyl‑4 (2′,3′‑methylenedioxy) phenyl‑2‑S‑ethyl‑1,4‑dihydropyrimidine have a calcium channel blocking activity and showed relaxant effect on aortic smooth muscle in higher doses as compared with Nifedipine. In order to ascertain the status of this compound as a drug, further studies are needed not only in other animals and tissue models but also in various pathophysiological models, since some drugs show more pronounced effect in disease and in pathophysiological models than in physiological conditions.

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      Kumar, R., Kaur, B., & Bajaj, V. K. (2013). Calcium channel blocking activity of a dihydropyrimidine derivative (BKVIII) on rabbit’s aortic strip. Journal of Pharmacology and Pharmacotherapeutics, 4(1), 64–66. https://doi.org/10.4103/0976-500X.107688