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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Comparison of the postoperative analgesia of intravenous infusion of adenosine and fentanyl

    Nagendra S. Chunduri1★, Tanveer Kollu2, Venkateswarulu R. Goteki3, Kiran K. Mallela4, Krishnaveni Madasu5★ Corresponding author

    1. 1Department of Oral and Maxillofacial surgery, BVU Dental College, Sangli, Maharashtra, India.
    2. 2SB Patil Dental College, Bidar, Karnataka, India.
    3. 3Pananeeya Table 1: Summed pain relief and pain intensity scores Drugs Mean TOPAR (±SD) Mean SPID (±SD) 8 h 24 h 8 h Aceclofenac 24.5 (±3) 72.7 (±8.54) 15.1 (±4.18) Diclofenac sodium 17.8 (±3) 58.4 (±12.4) 10.0 (±3.55) TOPAR=Total pain relief over; SPID=Summed PID over Table 2: Adverse events profile of study drugs Adverse event Aceclofenac Diclofenac sodium (n=25) (n=25) Nausea ‑ 2 Gastritis 1 3 Epigastric pain 1 4 Fluctuance 1 2 Indigestion 1 3 Hypersensitivity reactions 1 1 Dizziness 2 4 Total 7 19 Dental College, Hyderabad, India.
    4. 4Oral and Maxillofacial surgery, Kalinga Institute of Dental sciences, Bhubneswar, Odisha, India.
    5. 5Periodontics, GITAM Dental College, Vishakapatnam, Andhra Pradesh, India.

    CORRESPONDENCE

    Nagendra S. Chunduri

    Department of Oral and Maxillofacial surgery, BVU Dental College, Sangli, Maharashtra, India.

    srinivasomfs@gmail.com

    Volume 4, Issue 2 · pp. 145–148 · PUBLISHED 2013 · DOI: 10.4103/0976-500X.110910

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Significantly higher pain and FLACC behavior scale score were observed with fentanyl at 2 hours as compared to adenosine 15‑50 µg/kg/min [Table 1]. Fentanyl and adenosine 15‑50 µg/ kg/min had shown significantly less FLACC behavior scale scores at 8 hours as compared to adenosine 4‑6 µg/kg/min [Table 1]. Patients with adenosine 15‑50 µg/kg/min were more or less comfortable during the first 8 hours of study, whereas fentanyl group patients were more comfortable after 12 hours as observed with FLACC scale. Fukunaga et al. (2003) also observed significantly reduced pain scores in their study with adenosine.

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      Chunduri, N. S., Kollu, T., Goteki, V. R., Mallela, K. K., & Madasu, K. (2013). Comparison of the postoperative analgesia of intravenous infusion of adenosine and fentanyl. Journal of Pharmacology and Pharmacotherapeutics, 4(2), 145–148. https://doi.org/10.4103/0976-500X.110910