Volume 4, Issue 2

C‑section, formula may disrupt ‘good’ gut bacteria in babies

Sivagnanam G

pp. 166–7 · DOI: 10.4103/0976-500X.110922 · Published 2013

Early intestinal colonization with Lactobacilli and Bifidobacteria support the concept of their ability to modify the gut microbiota with beneficial roles like reduction in the risk of cancer due to their capacity to dec…

The enema of your enemy is your friend

pp. 166–166 · DOI: · Published 2013

Intestinal flora, called as microbiota, when disturbed has been associated with many GI and non‑GI diseases,[2] such diseases include, Clostridium difficile infection (CDI), inflammatory bowel disease (IBD), irritable bo…

Modulation of multidrug resistance 1 expression and function in retinoblastoma cells by curcumin

Seethalakshmi Sreenivasan, Sathyabaarathi Ravichandran, Umashankar Vetrivel

pp. 103–109 · DOI: 10.4103/0976-500X.110882 · Published 2013

Objective: To determine the possible interaction of curcumin with P‑glycoprotein (P‑gp) expression and function by in vitro and in silico studies. Materials and Methods: In this study, curcumin was compared for its poten…

Evaluation of acute physiological and molecular alterations in surgically developed hypothyroid Wistar rats

Maulik Patel, Vinay Mishra, Vaibhavi Pawar, Ramchandran Ranvir, Rajesh Sundar, Rajas Dabhi

pp. 87–93 · DOI: 10.4103/0976-500X.110891 · Published 2010

Objectives: To explore the general physiological and molecular changes occurring as a result of acute hypothyroidism. Materials and Methods: Hypothyroidism was developed by thyroidectomy in wistar rats. After surgery, an…

Assessment of proarrhythmic activity of chloroquine in in vivo and ex vivo rabbit models

Shailaja B. Khobragade, Pankaj Gupta, Prashant Gurav, Girish Chaudhari, Madhumanjiri M. Gatne

pp. 116–124 · DOI: 10.4103/0976-500X.110892 · Published 2013

Objectives: To evaluate the prolongation of ventricular repolarization and proarrhythmic activity of antimalarial drug chloroquine in two rabbit proarrhythmia models viz., in vivo α1 adrenoceptor‑stimulated anesthetized …

Insufficient stocking of cyanide antidotes in US hospitals that provide emergency care

Lucas Gasco, Margaret B. Rosbolt, Vikhyat S. Bebarta

pp. 95–102 · DOI: 10.4103/0976-500X.110875 · Published 2013

Objective: To identify the influence of catchment area, trauma center designation, hospital size, subspecialist employment, funding source, and other hospital characteristics on cyanide antidote stocking choice in US hos…

Scientific evaluation of the scholarly publications

Alok Saxena, Vijay Thawani, Mrinmoy Chakrabarty, Kunda Gharpure

pp. 125–126 · DOI: 10.4103/0976-500X.110894 · Published 2013

Worthiness of any scientific journal is measured by the quality of the articles published in it. The Impact factor (IF) is one popular tool which analyses the quality of journal in terms of citations received by its publ…

The critical steps for successful research: The research proposal and scientific writing (A report on the pre‑conference workshop held in conjunction with the 64th annual conference of the Indian Pharmaceutical Congress‑2012)

Pitchai Balakumar, Mohammed Naseeruddin Inamdar, Gowraganahalli Jagadeesh

pp. 178–182 · DOI: 10.4103/0976-500X.110895 · Published 2012

An interactive workshop on ‘The Critical Steps for Successful Research: The Research Proposal and Scientific Writing’ was conducted in conjunction with the 64th Annual Conference of the Indian Pharmaceutical Congress‑201…

Policy of reviewing statistics in Indian medical and surgical journals

S. Kannan, S. P. Deshpande, N. J. Gogtay, U. M. Thatte

pp. 139–140 · DOI: 10.4103/0976-500X.110897 · Published 2013

Although statistical methods are a vital part of research methodology, the quality of reporting statistics in published medical literature remains low containing a large number of statistical errors and deficiencies.[1‑3…

Cross sectional surveillance of drug dispensing efficacy, availability and quality of labelling by patient care indicators in health care facilities

Lukshmy M. Hettihewa, Kalana Jayarathna, Sewwandi Subasinghe

pp. 142–143 · DOI: 10.4103/0976-500X.110898 · Published 2013

Although modern medicine has changed for better dispensing managements, the evidence still continues to mount that adverse drug reactions to medicine related to dispensing practices. The risk associated with dispensing o…

Efficacy of aceclofenac and diclofenac sodium for relief of postoperative pain after third molar surgery: A randomised open label comparative study

Nagendra S. Chunduri, Tanveer Kollu, Venkateswarulu R. Goteki, Kiran K. Mallela, Krishnaveni Madasu

pp. 144–145 · DOI: 10.4103/0976-500X.110904 · Published 2013

This study was conducted among fifty patients, aged from 18‑60 years, who require surgical removal of impacted mandibular third molars. Patients with blood dyscrasias, with peptic ulcer, pregnant women, patients who had …

Comparison of the postoperative analgesia of intravenous infusion of adenosine and fentanyl

Nagendra S. Chunduri, Tanveer Kollu, Venkateswarulu R. Goteki, Kiran K. Mallela, Krishnaveni Madasu

pp. 145–148 · DOI: 10.4103/0976-500X.110910 · Published 2013

Significantly higher pain and FLACC behavior scale score were observed with fentanyl at 2 hours as compared to adenosine 15‑50 µg/kg/min [Table 1]. Fentanyl and adenosine 15‑50 µg/ kg/min had shown significantly less FLA…

Clozapine associated thrombocytopenia

Natasha Kate, Sandeep Grover, Munish Aggarwal, Pankaj Malhotra, Manupdesh S. Sachdeva

pp. 149–151 · DOI: 10.4103/0976-500X.110913 · Published 2013

Although agranulocytosis as a side effect of clozapine is well known, there is scarcity of data with regard to thrombocytopenia associated with clozapine. In this report we describe a case of clozapine induced thrombocyt…

Allopurinol induced granuloma annulare in a patient of lepromatous leprosy

Satyendra Kumar Singh, Kajal Manchanda, Aakash Amar Bhayana, Anurag Verma

pp. 152–154 · DOI: 10.4103/0976-500X.110915 · Published 2013

Granuloma annulare (GA) is a benign, inflammatory dermatosis involving dermis or subcutis with unknown etiology and poorly understood pathology. GA has characteristic histological features of necrobiosis, granuloma forma…

Diclofenac induced acute renal failure in a decompensated elderly patient

Pallavi Dhanvijay, Arup K. Misra, Sushil K. Varma

pp. 155–157 · DOI: 10.4103/0976-500X.110916 · Published 2013

Non‑steroidal anti‑inflammatory drugs (NSAIDs) are one of the most commonly prescribed drugs in post‑operative period worldwide. Their nephrotoxic effects are documented and accounts for around 15.5% of all cases of drug…

Dapsone hypersensitivity syndrome: A rare life threatening complication of dapsone therapy

Kolar Vishwanath Vinod, Karyampudi Arun, Tarun Kumar Dutta

pp. 158–160 · DOI: 10.4103/0976-500X.110917 · Published 2013

Dapsone can cause several adverse effects, the most serious being dapsone hypersensitivity syndrome (DHS), which is potentially fatal. Here we report a case of severe, life threatening dapsone systemic hypersensitivity s…

Caspofungin-induced fatal complete heart block: Another manifestation of Kounis syndrome

Nicholas G. Kounis

pp. 161–162 · DOI: 10.4103/0976-500X.110918 · Published 2013

In the very interesting report published recently in this Journal[1] a 58‑year‑old female patient, suffering from acute myeloid leukemia, developed bradycardia and hypotension culminating to fatal complete heart block, f…

Continued medical education credit hours: Are they being awarded too liberally?

Anupama Sukhlecha

pp. 164–165 · DOI: · Published 2013

Credit points are being distributed like prasad (temple offerings). Just to gain credit hours, doctors are attending different specialty CME meets.[5] Our body cannot be compartmentalized to subjects, so, any doctor can …

The portal for rare diseases and orphan drugs

Jatinder Singh

pp. 168–9 · DOI: · Published 2013

Orphan drugs are the stepchildren of the pharmaceutical industry. These medicinal products that are used primarily for the prevention or treatment of life‑threatening or debilitating rare diseases have restricted markets…

Bridging the gap between alternative medicine and evidence-based medicine

Mostafa Yakoot

pp. 83–85 · DOI: 10.4103/0976-500X.110868 · Published 2013

Complementary Alternative Medicine (CAM) was defined as “those treatments and health care practices that are not an integral part of conventional western medicine, not taught in medical schools, and not generally used in…

A review of computer assisted learning in medical undergraduates

Lisha J. John

pp. 86–90 · DOI: 10.4103/0976-500X.110870 · Published 2013

Laboratory based practical classes, have been the corner stone of undergraduate pharmacology learning. Ethical issues with the use of animals and rapid development of information technology has led to newer trends in tea…

Adverse drug reactions in the elderly

Dhriti K. Brahma, Julie B. Wahlang, Maxilline D. Marak, Marlina Ch. Sangma

pp. 91–92 · DOI: 10.4103/0976-500X.110872 · Published 2013

Medications probably are the single most important health care technology in preventing illness, disability, and death in the geriatric population. Age-related changes in drug disposition and pharmacodynamic responses ha…