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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Retrospective evaluation of adverse drug reactions induced by antihypertensive treatment

    Pierandrea Rende1, Laura Paletta2, Giuseppe Gallelli3, Gianluca Raffaele3, Vincenzo Natale3, Nazareno Brissa3, Cinzia Costa3, Santo Gratteri3, Chiara Giofrè3, Luca Gallelli3★★ Corresponding author

    1. 1Centro Regionale di Informazione sul farmaco, AO Mater Domini, Catanzaro, and Department of Health Science, School of Medicine, University of Catanzaro, Italy.
    2. 2Pugliese Ciaccio Hospital, Catanzaro, Italy.
    3. 3Azienda Sanitaria Vibo Valentia, Italy.

    CORRESPONDENCE

    Luca Gallelli

    Azienda Sanitaria Vibo Valentia, Italy.

    gallelli@unicz.it

    Volume 4, Issue 4S · pp. S47–S48 · PUBLISHED 2013 · DOI: 10.4103/0976-500X.120954

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    The use of cardiovascular drugs is related to the development of adverse drug reactions (ADRs) in about 24% of the patients in the Cardiovascular Care Unit. Here, we evaluated the ADRs in patients treated with antihypertensive drugs. The study was conducted in two phases: In the first phase, we performed a retrospective study on clinical records of Clinical Divisions (i.e., Internal Medicine Operative Unit and Geriatric Operative Unit) from January 1, 2012 to December 31, 2012. Moreover from January 1, 2013 to March 30, 2013 we performed a prospective study on the outpatients attending the Emergency Department (ED) of the Pugliese-Ciaccio Hospital of Catanzaro, by conducting patient interviews after their informed consent was obtained. The association between a drug and ADR was evaluated using the Naranjo scale. We recorded 72 ADRs in the Clinical Divisions and six in the ED, and these were more frequent in women. Using the Naranjo score, we showed a probable association in 92% of these reactions and a possible association in 8%. The most vulnerable age group involved in ADRs was that of the elderly patients. In conclusion, our results indicate that antihypertensive drugs may be able to induce the development of ADRs, particularly in elderly women receiving multiple drug treatment. Therefore, it is important to motivate the healthcare providers to understand their role and responsibility in the detection, management, documentation, and reporting of ADRs, as also all the essential activities for optimizing patient safety.

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      Rende, P., Paletta, L., Gallelli, G., Raffaele, G., Natale, V., Brissa, N., Costa, C., Gratteri, S., Giofrè, C., & Gallelli, L. (2013). Retrospective evaluation of adverse drug reactions induced by antihypertensive treatment. Journal of Pharmacology and Pharmacotherapeutics, 4(4S), S47–S48. https://doi.org/10.4103/0976-500X.120954