Oral carvedilol in escalating doses in the acute treatment of atrial fibrillation
Ravi Venkatachelam Chitrapu1★, Pentakota Ramana Rao1, Gangireddy Venkateswara Reddy1★ Corresponding author
- 1Department of Cardiology, Andhra Medical College, King George Hospital, Visakhapatnam, Andhra Pradesh, India.
CORRESPONDENCE
Ravi Venkatachelam Chitrapu
Department of Cardiology, Andhra Medical College, King George Hospital, Visakhapatnam, Andhra Pradesh, India.
Received: 15-06-2014; Revised: 21-06-2014; Accepted: 28-06-2014.
Volume 5, Issue 4 · pp. 239–244 · PUBLISHED 2014 · DOI: 10.4103/0976-500X.142430
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ABSTRACT
Objective: To study the efficacy of oral carvedilol in acute treatment of atrial fibrillation (AF) with fast ventricular rate. Materials and Methods: In an open‑label, single‑arm trial, oral carvedilol was administered to 35 patients of AF in escalating doses from 3.125 mg o.d. to 12.5 mg b.i.d. Results: A successful result was seen in 25 patients (71.4%) with 4 converting to sinus rhythm, rate control to less than 90 bpm in 16 and a 20% rate reduction in 5 patients. Two patients developed hypotension needing withdrawal of the drug. Conclusion: Escalating doses of oral carvedilol can be effectively and safely used in the acute treatment of AF with fast ventricular rate.
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Chitrapu, R. V., Rao, P. R., & Reddy, G. V. (2014). Oral carvedilol in escalating doses in the acute treatment of atrial fibrillation. Journal of Pharmacology and Pharmacotherapeutics, 5(4), 239–244. https://doi.org/10.4103/0976-500X.142430