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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Intravenous ranitidine: Rapid bolus can lead to cardiac arrest

    Kamlesh J Upadhyay1★, Sarita J Parmar1, Rohan Pravinbhai Parikh1, Prashant K Gauswami1, Nikunj Dadhaniya1, Abhilash Surela1★ Corresponding author

    1. 1Department of Medicine, B J Medical College, Ahmedabad, Gujarat, India.

    CORRESPONDENCE

    Kamlesh J Upadhyay

    Department of Medicine, B J Medical College, Ahmedabad, Gujarat, India.

    Received: 29-01-2014; Revised: 09-07-2014; Accepted: 11-09-2014.

    Volume 6, Issue 2 · pp. 100–102 · PUBLISHED 2015 · DOI: 10.4103/0976-500X.155489

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    This is a rare case report of a 30‑year‑old male, who was admitted to the Maxillofacial Surgery Department of the Dental College for a malunited fracture of the mandible and zygomatic bones. He was given oral medications namely, cefixime, metronidazole, ondansetron, and ranitidine for three days prior to the operation with complete normal preoperative workup. He had no significant past medical or family history. On the day of the operation, he was given injectable dexamethasone, cefotaxime, ondansetron, ranitidine, and metronidazole half-an-hour prior to the operation. In less than five minutes of giving a bolus ranitidine injection, the patient developed a cardiac arrest and was resuscitated by the anesthetist team on duty. He was transferred to the Intensive Care Unit (ICU) on a ventilator, which was soon removed and the patient was off vasopressors, with stable vitals for 24 hours after the event. He was then transferred to the general ward of Medicine Department and observed for a further two days during which the patient remained uneventful and was finally transferred back to the Dental Department.

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        Upadhyay, K. J., Parmar, S. J., Parikh, R. P., Gauswami, P. K., Dadhaniya, N., & Surela, A. (2015). Intravenous ranitidine: Rapid bolus can lead to cardiac arrest. Journal of Pharmacology and Pharmacotherapeutics, 6(2), 100–102. https://doi.org/10.4103/0976-500X.155489