Volume 6, Issue 2

Case Report

1. Article

   Intravenous ranitidine: Rapid bolus can lead to cardiac arrest

   Kamlesh J Upadhyay, Sarita J Parmar, Rohan Pravinbhai Parikh, Prashant K Gauswami, Nikunj Dadhaniya, Abhilash Surela

   pp. 100–102 · DOI: 10.4103/0976-500X.155489 · Published 2015

   This is a rare case report of a 30‑year‑old male, who was admitted to the Maxillofacial Surgery Department of the Dental College for a malunited fracture of the mandible and zygomatic bones. He was given oral medications…

2. Article

   Dexamethasone-induced withdrawal seizure

   Santwana Mahar, Mahima Malhotra

   pp. 103–104 · DOI: 10.4103/0976-500X.155490 · Published 2015

   Dexamethasone‑induced withdrawal seizure, which is a very rare and uncommon event, occurred after discontinuation of steroid therapy that was taken to increase weight by the patient. The pathogenesis is not well understo…

3. Article

   Hypersensitivity reaction with deferasirox

   Atul Sharma, Ekta Arora, Harmanjit Singh

   pp. 105–106 · DOI: 10.4103/0976-500X.155491 · Published 2015

   Thalassemias comprise a group of hereditary blood disorders. Thalassemia major presents with anemia within the first 2 years of life requiring frequent blood transfusions for sustaining life. Regular blood transfusions l…

4. Article

   Telmisartan aggravates pustular psoriasis

   Subramaniam Keerthi, Murugaiyan Rangaraj, Kaliaperumal Karthikeyan

   pp. 107–109 · DOI: 10.4103/0976-500X.155492 · Published 2015

   Pustular psoriasis is characterized by abrupt onset of macroscopic pustules associated with erythema and symptoms of burning pain and constitutional symptoms. There are several precipitating factors, both physiological s…

5. Article

   Adrenal suppression following herbal remedy for rheumatoid arthritis

   Balasekar Premkumar, Muppavarapu Srinivasa Murthy, Karuppasamy Rajagopal, Vadivelmurugan Nagasubramani Nagaprabu, Sree Madhuri Ponugupati

   pp. 110–113 · DOI: 10.4103/0976-500X.155493 · Published 2015

   A patient suffering from rheumatoid arthritis who had extreme adrenal suppression as a result of chronic use of herbal medicines presented with complications of adrenal suppression such as muscle weakness. He also had ps…

6. Article

   Olanzapine‑induced tender pitting pre‑tibial edema

   Kaliaperumal Mathan, Venkatesan Muthukrishnan, Vikas Menon

   pp. 114–115 · DOI: 10.4103/0976-500X.155494 · Published 2015

   Antipsychotic‑induced edema is uncommonly encountered in clinical practice. We report a case of tender pitting pre‑tibial edema with olanzapine in a woman with no medical comorbidities. The peculiar distribution of edema…

7. Article

   Hypokalemia and rhabdomyolysis

   Henrik Horwitz, Vidar A. Woeien, Linda Wiuff Petersen, Espen Jimenez‑Solem

   pp. 98–99 · DOI: 10.4103/0976-500X.155488 · Published 2015

   The adverse drug event manager of the Capital Region of Denmark received a report of a 65‑year‑old male with type II diabetes and long‑lasting treatment with indapamide. In addition, he had a history of a high consumptio…

Correspondence

1. Article

   VACCRaksha Calc: A computer program for the calculation of vaccine potency

   D = log10 of the dilution factor

   pp. · DOI: 10.4103/0976-500X.155495 · Published 2015, April-June 2015 | Vol 6 | Issue 2 | 116-117

   Assessment of vaccine potency is often carried out by veterinarians in animal house in biological units. The more reliable method used for this assessment is Spearman and Karber. The calculations involved in the assessme…

1. Article

   Suvorexant: The first orexin receptor antagonist to treat insomnia

   Ashok K. Dubey, Shailendra S. Handu, Pramod K. Mediratta

   pp. 118–121 · DOI: 10.4103/0976-500X.155496 · Published 2015

   Primary insomnia is mainly treated with drugs acting on benzodiazepine receptors and a few other classes of drugs used for different co‑morbidities. A novel approach to treat insomnia has been introduced recently, with t…

Editorial

1. Forum Article

   Principles and practice of plagiarism: Perpetrators’ perspective

   Amitav Banerjee

   pp. 61–62 · DOI: 10.4103/0976-500X.155480 · Published 2015

Review Article

1. Review

   Scientific concepts and applications of integrated discrete multiple organ co-culture technology

   Loganathan Gayathri, Dharumadurai Dhanasekaran, Mohammad A. Akbarsha

   pp. 63–70 · DOI: 10.4103/0976-500X.155481 · Published 2015

   Over several decades, animals have been used as models to investigate the human‑specific drug toxicity, but the outcomes are not always reliably extrapolated to the humans in vivo. Appropriate in vitro human‑based experi…

2. Review

   Efficacy of novel monoclonal antibody belimumab in the treatment of lupus nephritis

   Marianne Frieri, William Heuser, Joshua Bliss

   pp. 71–76 · DOI: 10.4103/0976-500X.155482 · Published 2015

   Recently introduced into the market, belimumab (Benlysta) is a monoclonal antibody that has potential clinically efficacious applications for the treatment of lupus nephritis. Lupus nephritis is a major complication of s…

Research Paper

1. Article

   Identification of core active disaccharides in heparin for HGF‑inducing activity

   Takashi Kato, Ryoichi Sakiyama, Kiyomasa Oka, Toshikazu Nakamura

   pp. 77–82 · DOI: 10.4103/0976-500X.155483 · Published 2015

   Objectives: To ascertain the positions of sulfated groups for HGF‑inducing activity using differently sulfated heparin disaccharides and to investigate whether the heparin disaccharide elevates HGF levels in plasma in vi…

2. Article

   Prescription errors in cancer chemotherapy: Omissions supersede potentially harmful errors

   Jayanthi Mathaiyan, Tanvi Jain, Biswajit Dubashi, K Satyanarayana Reddy, Gitanjali Batmanabane

   pp. 83–87 · DOI: 10.4103/0976-500X.155484 · Published 2015

   Objective: To estimate the frequency and type of prescription errors in patients receiving cancer chemotherapy. Settings and Design: We conducted a cross‑sectional study at the day care unit of the Regional Cancer Centre…

Research Letter

1. Article

   Parents’ awareness and perspective on off‑label medicines use in children

   Mohd Masnoon Saiyed, Aarohi Prajapati, Gaurang Shah

   pp. 88–89 · DOI: · Published 2015

   The lack of pediatric drug labeling is a long-standing problem for prescribers and drug regulatory bodies. As a result, medicines are prescribed in an off-label manner, which is inconsistent with its approved prescribing…

2. Article

   Comparison of agreement and rational uses of the WHO and Naranjo adverse event causality assessment tools

   Niti Mittal, Mahesh C. Gupta

   pp. 91–93 · DOI: 10.4103/0976-500X.155486 · Published 2015

   Causality assessment of adverse events (AEs) is the standardized and detailed assessment of individual case safety reports for the likelihood of involvement of the suspected drug/s in causing the particular AE. The basic…

Commentary

1. Article

   Violation of publication ethics in manuscripts: Analysis and perspectives

   Subramani Parasuraman, Ramasamy Raveendran, K. K. Mueen Ahmed

   pp. 94–95 · DOI: 10.4103/0976-500X.155487 · Published 2015