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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Review

    Efficacy of novel monoclonal antibody belimumab in the treatment of lupus nephritis

    Marianne Frieri1, William Heuser2★, Joshua Bliss2★ Corresponding author

    1. 1Department of Medicine, Nassau University Medical Center, USA.
    2. 2Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St Johns University, New York, USA.

    CORRESPONDENCE

    William Heuser

    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St Johns University, New York, USA.

    william.heuser08@my.stjohns.edu

    Received: 10-09-2014; Revised: 20-10-2014; Accepted: 15-11-2014.

    Volume 6, Issue 2 · pp. 71–76 · PUBLISHED 2015 · DOI: 10.4103/0976-500X.155482

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Recently introduced into the market, belimumab (Benlysta) is a monoclonal antibody that has potential clinically efficacious applications for the treatment of lupus nephritis. Lupus nephritis is a major complication of systemic lupus erythematosus (SLE) that can lead to significant illness or even death without proper intervention and treatment. With vast implications through a novel mechanism, belimumab offers a new standard of treatment for physicians in the complications associated with SLE, specifically lupus nephritis. By targeting B cell signaling and maturation, belimumab is able to mitigate the underlying pathological complications surrounding SLE. Phase 3 clinical trials with belimumab have depicted clinically efficacious applications, suggesting belimumab as a revolutionary breakthrough in the treatment armamentarium for practicing clinicians. This article explains the precise mechanism of action of belimumab on the soluble protein BlyS that plays a major role in the pathogenesis of lupus nephritis. In addition, the extensive pharmacokinetics and clinical implications are exemplified in this review with belimumab’s comparison with standard therapeutic guidelines for the treatment of lupus nephritis.

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      Frieri, M., Heuser, W., & Bliss, J. (2015). Efficacy of novel monoclonal antibody belimumab in the treatment of lupus nephritis. Journal of Pharmacology and Pharmacotherapeutics, 6(2), 71–76. https://doi.org/10.4103/0976-500X.155482