Comparison of anti-inflammatory effect of atorvastatin with rosuvastatin in patients of acute coronary syndrome

ABSTRACT

Objectives: To compare anti‑inflammatory effect of atorvastatin and rosuvastatin in patients of acute coronary syndrome. Materials and Methods: The study was a prospective, open‑labeled, randomized and single‑center study conducted on 100 patients of acute coronary syndrome. Patients were assigned to atorvastatin 40 mg daily or rosuvastatin 20 mg daily for 4 weeks. C‑reactive protein (CRP) levels, lipid profiles, erythrocyte sedimentation rate (ESR) and adverse effects were measured at beginning and at the end of 4 weeks. Results: Baseline parameters and clinical profile did not differ between the two groups. CRP levels significantly decreased from beginning to the end of 4 weeks in both atorvastatin and rosuvastatin groups (from 35.48 to 23.07 mg/l and from 35.88 to 19.91 mg/l respectively, both P < 0.001). However, there was significant difference between the levels of CRP in patients of the rosuvastatin group as compared to the atorvastatin group (19.91 ± 6.32 vs 23.07 ± 7.47, P < 0.05). In addition, both the drugs were associated with a reduction in total cholesterol, LDL levels and ESR at the end of 4 weeks as compared to the beginning (P < 0.001 for all comparisons). Conclusion: Both atorvastatin (40 mg) and rosuvastatin (20 mg) are effective in decreasing CRP and LDL cholesterol levels even in a short duration of 4 weeks. Rosuvastatin was found to be more effective in decreasing CRP levels.

KEYWORDS

• Acute coronary syndrome
• inflammation
• statins

Showing references and in-text citations exactly as published.

Cite this article

• DOI10.4103/0976-500X.162011Copy

RELATED ARTICLES

Matched on volume, issue, section and article type within J Pharmacol. Pharmacother..

• Article · VOLUME 6, ISSUE 3Inhibition by sildenafil of contractility of isolated non‑pregnant human myometriumAruldhas Blessed Winston, Kaysina Vazhudhi, Sumalya Sen, Elsy Thomas, Santhosh Benjamin · pp. 136–141Research PaperSame type: ArticleSame issue
• Article · VOLUME 6, ISSUE 3Effectiveness of vitamin D3 in severe persistent asthmatic patients: A double blind, randomized, clinical studyMuhasaparur Ganesan Rajanandh, Arcot D. Nageswari, Giridharan Prathiksha · pp. 142–146Research PaperSame type: ArticleSame issue
• Article · VOLUME 6, ISSUE 3The effects of A2B receptor modulators on vascular endothelial growth factor and nitric oxide axis in chronic cyclosporine nephropathyLeena Patel, Aswin Thaker · pp. 147–148Research PaperSame type: ArticleSame issue
• Article · VOLUME 6, ISSUE 1Phosphodiesterase-4 inhibition with rolipram attenuates hepatocellular injury in hyperinflammation in vivo and in vitro without influencing inflammation and HO-1 expressionJakob Wollborn, Christian Wunder, Jana Stix, Winfried Neuhaus, Rapahel R. Bruno, Wolfgang Baar, Sven Flemming, Norbert Roewer, Nicolas Schlegel, Martin A.Schick · pp. Research PaperSame type: ArticleVolume 6