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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Effectiveness of vitamin D3 in severe persistent asthmatic patients: A double blind, randomized, clinical study

    Muhasaparur Ganesan Rajanandh1, Arcot D. Nageswari2★, Giridharan Prathiksha3★ Corresponding author

    1. 1Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, India.
    2. 2Department of Pulmonary Medicine, SRM Medical College Hospital and Research Center, SRM University, Kattankulathur, India.
    3. 3Department of Community Medicine, ESIC PGIMSR Medical College, KK Nagar, Chennai, Tamil Nadu, India.

    CORRESPONDENCE

    Arcot D. Nageswari

    Department of Pulmonary Medicine, SRM Medical College Hospital and Research Center, SRM University, Kattankulathur, India.

    dradnageswari@yahoo.com

    Received: 25-12-2014; Revised: 18-01-2015; Accepted: 15-05-2015.

    Volume 6, Issue 3 · pp. 142–146 · PUBLISHED 2015 · DOI: 10.4103/0976-500X.162022

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objective: To assess the pulmonary function and quality of life in asthma patients receiving vitamin D3 supplementation with inhaled budesonide and formoterol. Materials and Methods: This was a double blinded, randomized, comparative study. Patients were recruited as per the study criteria and randomized into two groups: usual care group (n = 69) patients received budesonide (800 µg) with formoterol (24 µg) and intervention care group (n = 72) patients received vitamin D3 (1000 IU) supplementation along with budesonide (800 µg) plus formoterol (24 µg) for a period of 6 months. Results: A total of 140 patients completed the study. Significant within‑group improvement and non‑significant between‑group improvement is observed with respect to FEV1. In terms of health‑related quality of life, within‑group comparison revealed a significant (P < 0.05) improvement in all the domains of SGRQ. However, between‑group comparisons showed statistically significant (P < 0.05) improvement in symptom, impact and total scores. Conclusion: On the basis of our findings, we conclude that supplementation of vitamin D3 is effective in improving the quality of life rather than pulmonary function in severe asthmatics. However, further studies are warranted to substantiate the present findings.

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      Rajanandh, M. G., Nageswari, A. D., & Prathiksha, G. (2015). Effectiveness of vitamin D3 in severe persistent asthmatic patients: A double blind, randomized, clinical study. Journal of Pharmacology and Pharmacotherapeutics, 6(3), 142–146. https://doi.org/10.4103/0976-500X.162022