Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Double trouble: Cyclosporine‑induced thrombocytosis in a patient with methotrexate toxicity: Are they related?

    Cherukuri Tejaswi1★, Saritha Mohanan1, Rangaraj Murugaiyan1, Kaliaperumal Karthikeyan1★ Corresponding author

    1. 1Department of Dermatology, Sri Manakula Vinayagar Medical College and Hospital, Kalitheerthalkuppam, Puducherry, India.

    CORRESPONDENCE

    Cherukuri Tejaswi

    Department of Dermatology, Sri Manakula Vinayagar Medical College and Hospital, Kalitheerthalkuppam, Puducherry, India.

    Received: 09-05-2014; Revised: 21-06-2014; Accepted: 22-01-2015.

    Volume 6, Issue 3 · pp. 160–162 · PUBLISHED 2015 · DOI: 10.4103/0976-500X.162005

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Psoriasis is a common, chronic, disfiguring, inflammatory, and proliferative condition of the skin. It manifests with varying degrees of severity and can be treated with various immune modulators. This is a case report of a 57‑year‑old male patient of psoriasis on long‑term oral methotrexate, who developed methotrexate toxicity when given an injection of methotrexate for unstable psoriasis. After recovery, the patient was started on cyclosporine 100 mg twice a day. After a week, he developed thrombocytosis, which reverted a week after cyclosporine was stopped. The patient is currently being managed with acitretin. The aim of this case report is to emphasize the various unpredictable adverse reactions encountered during treatment of psoriasis, especially when a combination or sequential treatment is used. There is a need for caution, as late sequelae of long‑term administration of the systemic agents used in the treatment of psoriasis are still unknown.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Tejaswi, C., Mohanan, S., Murugaiyan, R., & Karthikeyan, K. (2015). Double trouble: Cyclosporine‑induced thrombocytosis in a patient with methotrexate toxicity: Are they related?. Journal of Pharmacology and Pharmacotherapeutics, 6(3), 160–162. https://doi.org/10.4103/0976-500X.162005