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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Complete resistance after maximal dose of rocuronium

    Annalisa Capuano1★, Maria Giuseppa Sullo1, Concetta Rafaniello1, Liberata Sportiello1, Pierfrancesco Fusco2, Macella De Vizia3, Fausto Ferraro3★ Corresponding author

    1. 1Department of Experimental Medicine, Section of Pharmacology, Pharmacoepidemiology and Pharmacovigilance Center of the Campania Region, Second University of Naples, Italy.
    2. 2Department of Anesthesia and Intensive Care, San Salvatore Hospital, L’Aquila, Italy.
    3. 3Department of Anesthetic, Surgical, and Emergency Science ‑ Intensive Care Unit, Second University of Naples, Naples, Italy.

    CORRESPONDENCE

    Annalisa Capuano

    Department of Experimental Medicine, Section of Pharmacology, Pharmacoepidemiology and Pharmacovigilance Center of the Campania Region, Second University of Naples, Italy.

    Received: 17-07-2014; Revised: 06-09-2014; Accepted: 21-12-2014.

    Volume 6, Issue 3 · pp. 175–178 · PUBLISHED 2015 · DOI: 10.4103/0976-500X.162012

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Rocuronium is a non‑depolarizing neuromuscular blocking agent (NDNMBA), employed in the clinic as an adjunct to general anesthesia to facilitate tracheal intubation rapid sequence, and to provide skeletal muscle relaxation during surgery. Many cases of resistance to neuromuscular blocking agents (NMBAs) have been anecdotally reported. There are specific pathologic states, such as upper motor neuron lesions, severe thermal injuries, liver disease, renal failure, disuse atrophy, all of which show an increased resistance to the effects of nondepolarizing muscle relaxants. Also concurrent drug therapy can alter the efficacy of NMBAs such as some classes of antibiotics, furosemide, β receptor agonists, phosphodiesterase inhibitors, calcium antagonists, respiratory stimulants but also ketamine, propofol and barbiturates at high concentrations. In this scenario we describe an unusual case of 20‑years‑old man who showed a complete resistance to rocuronium maybe due to a glucocorticoids concomitant therapy.

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      Capuano, A., Sullo, M. G., Rafaniello, C., Sportiello, L., Fusco, P., Vizia, M. D., & Ferraro, F. (2015). Complete resistance after maximal dose of rocuronium. Journal of Pharmacology and Pharmacotherapeutics, 6(3), 175–178. https://doi.org/10.4103/0976-500X.162012