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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Sodium Glucose Transporter 2 Inhibitors and Diabetic Ketoacidosis in Three Patients with Diabetes: Underlying Causation

    Jordan L. Kelley1,2, Matthew Strum1,3, Daniel M. Riche1,4★, Andrew M. Chandler5★ Corresponding author

    1. 1The University of Mississippi School of Pharmacy, Jackson, MS, US.
    2. 2The University of Kentucky HealthCare, Lexington, KY, US.
    3. 3Novo Nordisk, Plainsboro, NJ, US.
    4. 4The University of Mississippi School of Medicine, Jackson, MS, US.
    5. 5Oxford Endocrinology Consultants, Oxford, MS, US.

    CORRESPONDENCE

    Daniel M. Riche

    The University of Mississippi School of Pharmacy, Jackson, MS, US.

    driche@umc.edu

    Received: 02-06-2017; Revised: 10-09-2017; Accepted: 07-10-2017.

    Volume 8, Issue 3 · pp. 137–9 · PUBLISHED 2017 · DOI: 10.4103/jpp.JPP_20_17

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Sodium glucose transporter 2 inhibitors (SGLT2i) inhibit the reabsorption of glucose in the renal tubules reducing glycemia and increasing glucosuria. The increased glucosuria causes a shift in normal flora and colonization of pathogenic microorganisms leading to an increase in mycotic genital infections. Recent Food and Drug Administration reported cases of diabetic ketoacidosis (DKA) after initiation of SGLT2i probes the question of safety with such agents. The mechanisms of ketoacidosis and the breakdown of lipids are often misunderstood, and blame is placed on lack of insulin or on medications used to treat diabetes. However, many patients living with diabetes do not experience DKA if the proper treatment and management of concomitant comorbidities are addressed. After a retrospective chart review of 250 patients, three patients were identified with DKA while on SGLT2i, but for three distinct contrasting reasons. Assessment of the pharmacodynamics of SGLT2i and the pathophysiology of DKA infers that emphasis for prevention of SGLT2i-associated DKA should be placed on appropriate diagnosis, infection, and electrolyte abnormalities.

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      Kelley, J. L., Strum, M., Riche, D. M., & Chandler, A. M. (2017). Sodium Glucose Transporter 2 Inhibitors and Diabetic Ketoacidosis in Three Patients with Diabetes: Underlying Causation. Journal of Pharmacology and Pharmacotherapeutics, 8(3), 137–9. https://doi.org/10.4103/jpp.JPP_20_17